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Fluorescein isothiocyanate-dextran | CAS 60842-46-8
| Catalog Number | F04-0036 |
| Category | Fluorescein FAM |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Fluorescein isothiocyanate-dextran (FITC-dextran) is a fluorescently labeled polysaccharide used in biological and biochemical applications. Comprising fluorescein isothiocyanate (FITC) and dextran, it emits green fluorescence when excited by blue light. FITC-dextran is commonly used to study cell permeability, endocytosis, and intracellular processes, and it serves as a tracer in vascular studies and tissue distribution in live animals. It is highly sensitive, versatile, and non-toxic, making it ideal for fluorescence microscopy and in vivo imaging.
Chemical Information
Product Specification
Application
| Synonyms | Fluorescein Isothiocyanate Dextran (Mw.=ca. 10000); FITC-Dextran 2000; Dextran, N-(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5(or 6)-yl)carbamothioate; Dextran, (3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5(or 6)-yl)carbamothioate; Fluorescein isothiocyanate-dextran - Average MW 3,000-5,000; Dextran-FITC; FD 10S; FITC-dextran; FITC-dextran 64 |
| Solubility | Soluble in Water |
| Appearance | Yellow to orange powder |
| MDL Number | MFCD00131092 |
| Excitation | 495 nm |
| Emission | 518 nm |
| Condition To Avoid | Heat Sensitive |
| Storage | Store at 2-8 °C |
Fluorescein isothiocyanate-dextran (FITC-dextran), a versatile molecule with an average molecular weight of 3000-5000, finds extensive use in biological research. Here are four key applications of FITC-dextran:
Vascular Permeability Studies: A cornerstone in studies of vascular permeability and blood-brain barrier integrity, FITC-dextran serves as a ubiquitous tool. By introducing FITC-dextran into the bloodstream and monitoring its leakage into adjacent tissues, researchers can probe endothelial barrier functionality across diverse experimental settings. This application is pivotal in unraveling the complexities of conditions such as inflammation, cancer, and stroke.
Cell Tracking: In the realm of cell tracking, FITC-dextran emerges as a luminary, aiding in the labeling and monitoring of cells both in vitro and in vivo. By integrating FITC-dextran into cell cultures or animal models, scientists can visualize and track the movement, proliferation, and localization of cells through the lens of fluorescence microscopy. This technique is indispensable for studies in cell migration, tissue engineering, and regenerative medicine.
Lymphatic Flow Analysis: An essential component of research on lymphatic flow and drainage, FITC-dextran lends its prowess to investigations within the lymphatic system. When administered into lymphatic vessels, FITC-dextran enables the visualization and quantification of lymphatic trafficking and function. This application stands as a cornerstone in delving into disorders associated with lymphatic circulation, including lymphedema and metastasis.
Binding and Uptake Studies: Delving into the intricacies of cellular interactions, FITC-dextran emerges as a key player in deciphering binding and uptake mechanisms at the cellular and tissue levels. Through incubating cells with FITC-dextran, researchers can explore endocytic pathways, receptor-mediated uptake, and internalization processes. This application holds significance in unraveling cellular transport mechanisms, drug delivery systems, and nanoparticle behaviors.
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