Fluorescein isothiocyanate-dextran | CAS 60842-46-8

Name: Fluorescein isothiocyanate-dextran
Brand: BOC Sciences
Rating: 5 (1 reviews)

Catalog Number	F04-0036
Category	Fluorescein FAM

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Product Introduction

FITC-dextran is a fluorescent polysaccharide tracer for permeability, phagocytosis, and vascular studies. It provides bright, stable fluorescence for biological imaging.

Chemical Information
Product Specification
Application

Synonyms	Fluorescein Isothiocyanate Dextran (Mw.=ca. 10000); FITC-Dextran 2000; Dextran, N-(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5(or 6)-yl)carbamothioate; Dextran, (3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5(or 6)-yl)carbamothioate; Fluorescein isothiocyanate-dextran - Average MW 3,000-5,000; Dextran-FITC; FD 10S; FITC-dextran; FITC-dextran 64
Solubility	Soluble in Water
Appearance	Yellow to orange powder
MDL Number	MFCD00131092

Excitation	495 nm
Emission	518 nm
Condition To Avoid	Heat Sensitive
Storage	Store at 2-8 °C

Fluorescein isothiocyanate-dextran (FITC-dextran), a versatile molecule with an average molecular weight of 3000-5000, finds extensive use in biological research. Here are four key applications of FITC-dextran:

Vascular Permeability Studies: A cornerstone in studies of vascular permeability and blood-brain barrier integrity, FITC-dextran serves as a ubiquitous tool. By introducing FITC-dextran into the bloodstream and monitoring its leakage into adjacent tissues, researchers can probe endothelial barrier functionality across diverse experimental settings. This application is pivotal in unraveling the complexities of conditions such as inflammation, cancer, and stroke.

Cell Tracking: In the realm of cell tracking, FITC-dextran emerges as a luminary, aiding in the labeling and monitoring of cells both in vitro and in vivo. By integrating FITC-dextran into cell cultures or animal models, scientists can visualize and track the movement, proliferation, and localization of cells through the lens of fluorescence microscopy. This technique is indispensable for studies in cell migration, tissue engineering, and regenerative medicine.

Lymphatic Flow Analysis: An essential component of research on lymphatic flow and drainage, FITC-dextran lends its prowess to investigations within the lymphatic system. When administered into lymphatic vessels, FITC-dextran enables the visualization and quantification of lymphatic trafficking and function. This application stands as a cornerstone in delving into disorders associated with lymphatic circulation, including lymphedema and metastasis.

Binding and Uptake Studies: Delving into the intricacies of cellular interactions, FITC-dextran emerges as a key player in deciphering binding and uptake mechanisms at the cellular and tissue levels. Through incubating cells with FITC-dextran, researchers can explore endocytic pathways, receptor-mediated uptake, and internalization processes. This application holds significance in unraveling cellular transport mechanisms, drug delivery systems, and nanoparticle behaviors.