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Ac-DEVD-AMC | 169332-61-0
| Catalog Number | A18-0013 |
| Category | Fluorescent Enzyme Substrates |
| Molecular Formula | C30H37N5O13 |
| Molecular Weight | 675.64 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| A18-0013 | -- | $-- |
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Product Introduction
Ac-DEVD-AMC is a fluorogenic substrate for caspase-3. Caspase activity can be quantified by fluorescent detection of free AMC (7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm.
Chemical Information |
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|---|---|
| Synonyms | N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-Methylcoumarin; N-acetyl-L-α-aspartyl-L-α-glutamyl-L-valyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-α-asparagine |
| Purity | ≥95% |
| IUPAC Name | (4S)-4-[[(2S)-2-acetamido-3-carboxypropanoyl]amino]-5-[[(2S)-1-[[(2S)-3-carboxy-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-oxopentanoic acid |
| Canonical SMILES | CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)C(CC(=O)O)NC(=O)C(C(C)C)NC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C |
| InChI | InChI=1S/C30H37N5O13/c1-13(2)26(35-27(44)18(7-8-22(37)38)33-29(46)19(11-23(39)40)31-15(4)36)30(47)34-20(12-24(41)42)28(45)32-16-5-6-17-14(3)9-25(43)48-21(17)10-16/h5-6,9-10,13,18-20,26H,7-8,11-12H2,1-4H3,(H,31,36)(H,32,45)(H,33,46)(H,34,47)(H,35,44)(H,37,38)(H,39,40)(H,41,42)/t18-,19-,20-,26-/m0/s1 |
| InChI Key | ALZSTTDFHZHSCA-RNVDEAKXSA-N |
| Density | 1.423±0.06 g/cm3 |
| Boiling Point | 1200.1±65.0 °C at 760 mmHg |
- Product Specification
| Excitation | 340-360 nm |
| Emission | 440-460 nm |
| Storage | Store at -20°C |
Computed Properties | |
|---|---|
| XLogP3 | -1.3 |
| Hydrogen Bond Donor Count | 8 |
| Hydrogen Bond Acceptor Count | 13 |
| Rotatable Bond Count | 17 |
| Exact Mass | 675.23878625 g/mol |
| Monoisotopic Mass | 675.23878625 g/mol |
| Topological Polar Surface Area | 284Ų |
| Heavy Atom Count | 48 |
| Formal Charge | 0 |
| Complexity | 1330 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 4 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 25446497 | 2014-12-05 | Isolation and prevention of calcium oxalate-induced apoptotic death and oxidative stress in MDCK cells by diosgenin | Chemico-biological interactions |
| 19364322 | 2009-03-01 | A secreted caspase-3-substrate-cleaving activity at low pH belongs to cathepsin B: a study on primary brain cell cultures | Biochemistry. Biokhimiia |
| 18393770 | 2008-03-01 | Brain cathepsin B cleaves a caspase substrate | Biochemistry. Biokhimiia |
| 17678535 | 2007-08-01 | PepBank--a database of peptides based on sequence text mining and public peptide data sources | BMC bioinformatics |
| 16517063 | 2007-01-08 | Bis(2-hydroxybenzylidene)acetone, a potent inducer of the phase 2 response, causes apoptosis in mouse leukemia cells through a p53-independent, caspase-mediated pathway | Cancer letters |
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| EP-3929209-A1 | Vasopressin-2 receptor antagonist peptides and uses thereof | 2020-06-24 |
| KR-20220158727-A | Methods for enriching and expanding tumor-reactive T cells ex vivo and compositions related thereto | 2020-02-27 |
| WO-2021127187-A1 | Rna nanoparticle for liver cancer treatment | 2019-12-20 |
| US-2022372493-A1 | Rna nanoparticle for liver cancer treatment | 2019-12-20 |
| JP-2023504042-A | Methods of generating tumor-reactive T-cell compositions using modulators | 2019-11-27 |
Applications of Fluorescent Probes & Dyes
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