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PHOME | 1028430-42-3
| Catalog Number | A18-0065 |
| Category | Fluorescent Enzyme Substrates |
| Molecular Formula | C23H19NO4 |
| Molecular Weight | 373.4 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| A18-0065 | -- | $-- |
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Product Introduction
PHOME is a fluorogenic substrate for human soluble epoxide hydrolase (sEH) that can be used to monitor the activity of sEH. PHOME is stable in aqueous solution and is useful in high throughput screening (HTS) programs.
Chemical Information |
|
|---|---|
| Synonyms | 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methyl ester-2-oxiraneacetic acid |
| Purity | ≥98% |
| IUPAC Name | [cyano-(6-methoxynaphthalen-2-yl)methyl] 2-(3-phenyloxiran-2-yl)acetate |
| Canonical SMILES | COC1=CC2=C(C=C1)C=C(C=C2)C(C#N)OC(=O)CC3C(O3)C4=CC=CC=C4 |
| InChI | InChI=1S/C23H19NO4/c1-26-19-10-9-16-11-18(8-7-17(16)12-19)21(14-24)27-22(25)13-20-23(28-20)15-5-3-2-4-6-15/h2-12,20-21,23H,13H2,1H3 |
| InChI Key | NZOVBSWOWQLAJG-UHFFFAOYSA-N |
| Appearance | Solid Powder |
- Product Specification
| Storage | Store at -20°C |
Computed Properties | |
|---|---|
| XLogP3 | 4 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 7 |
| Exact Mass | 373.13140809 g/mol |
| Monoisotopic Mass | 373.13140809 g/mol |
| Topological Polar Surface Area | 71.8Ų |
| Heavy Atom Count | 28 |
| Formal Charge | 0 |
| Complexity | 593 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 3 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 16729954 | 2006-08-01 | Development of a high-throughput screen for soluble epoxide hydrolase inhibition | Analytical biochemistry |
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| WO-2022267470-A1 | Seh inhibitor or pharmaceutically acceptable composition thereof, and preparation method therefor and use thereof | 2021-06-22 |
| EP-4063348-A1 | Compounds as soluble epoxide hydrolase inhibitors | 2021-03-24 |
| WO-2022200105-A1 | Compounds as soluble epoxide hydrolase inhibitors | 2021-03-24 |
| WO-2020193448-A1 | Multitarget compounds for the treatment of alzheimer's disease | 2019-03-28 |
| EP-3584236-A1 | Polycyclic compounds soluble epoxide hydrolase inhibitors | 2018-06-20 |
Applications of Fluorescent Probes & Dyes
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