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Oxonol V | CAS 61389-30-8
| Catalog Number | A16-0169 |
| Category | Cell membrane Fluorescent Probes |
| Molecular Formula | C23H16N2O4 |
| Molecular Weight | 384.38 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Oxonol V is a slow-response sensitive probe for measuring cellular membrane potential.
Chemical Information
Product Specification
Application
Computed Properties
Patents
| Synonyms | (4Z)-4-[(2E,4E)-5-(5-oxo-3-phenyl-2H-1,2-oxazol-4-yl)penta-2,4-dienylidene]-3-phenyl-1,2-oxazol-5-one; Ox-V bis(3-phenyl-5-oxoisoxazol-4-yl)pentamethinoxonol; 1,5-Bis(3-phenyl-5-oxoisoxazol-4-yl)pentamethine oxonol; Ox-Vbis(3-phenyl-5-oxoisoxazol-4-yl)pentamethinoxonol; 1,5-Penta-1,3-dien-1-yl-5-ylidene-bis(5-oxo-3-phenyl-4-isoxazole); 4-(5-(5-HYDROXY-3-PHENYL-4-ISOXAZOLYL)-2,4-PENTADIEN-1-YLIDENE)-3-PHENYL-5(4H)-ISOXAZOLONE;5(4H)-ISOXAZOLONE, 4-(5-(5-HYDROXY-3-PHENYL-4-ISOXAZOLYL)-2,4-PENTADIEN-1-YLIDENE)-3-PHENYL- |
| IUPAC Name | (4Z)-4-[(2E,4E)-5-(5-oxo-3-phenyl-2H-1,2-oxazol-4-yl)penta-2,4-dienylidene]-3-phenyl-1,2-oxazol-5-one |
| Canonical SMILES | C1=CC=C(C=C1)C2=C(C(=O)ON2)C=CC=CC=C3C(=NOC3=O)C4=CC=CC=C4 |
| InChI | InChI=1S/C23H16N2O4/c26-22-18(20(24-28-22)16-10-4-1-5-11-16)14-8-3-9-15-19-21(25-29-23(19)27)17-12-6-2-7-13-17/h1-15,24H/b9-3+,14-8+,19-15- |
| InChIKey | KUINQLKLKSFJME-UFRBDIPQSA-N |
| Signal | Warning |
| GHSHazardStatements | H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] |
| Precautionary Statement Codes | P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.) |
Oxonol V, a membrane potential-sensitive dye, finds widespread application in scientific research. Here are four key uses of Oxonol V:
Cell Viability Assays: In cell culture experiments, Oxonol V plays a pivotal role in assessing cell viability and membrane potential alterations. By introducing Oxonol V, researchers can precisely determine the proportion of viable cells through fluorescence intensity analysis. This tool proves invaluable in investigations concerning drug toxicity and the assessment of cytoprotective agents.
Mitochondrial Function Studies: Delving into live cells, Oxonol V offers a pathway to explore mitochondrial membrane potential, especially in cells exhibiting depolarized mitochondria. With its unique property of accumulation in dysfunctional mitochondria, this dye aids in identifying mitochondrial irregularities. Such insights are crucial for understanding diseases associated with mitochondrial dysfunction, such as neurodegenerative conditions and metabolic syndromes.
Electrophysiology Research: Within the realm of electrophysiology, Oxonol V emerges as a vital tool for visualizing and quantifying changes in membrane potential. Researchers leverage this dye to track the dynamics of ion channel activity and action potentials in excitable cells. This information proves essential for unraveling the electrical characteristics of tissues and paving the way for the development of innovative pharmaceuticals targeting ion channels.
Flow Cytometry: By utilizing Oxonol V in flow cytometry, researchers gain a powerful tool for assessing changes in membrane potential at a single-cell level. Staining cells with this dye enables the distinction of different cell populations based on their membrane potential status. This technique proves invaluable in diverse fields such as immunology, oncology, and cell biology research, aiding in the characterization of cell health and functional status.
| XLogP3 | 5.2 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 5 |
| Exact Mass | 384.11100700 g/mol |
| Monoisotopic Mass | 384.11100700 g/mol |
| Topological Polar Surface Area | 77Ų |
| Heavy Atom Count | 29 |
| Formal Charge | 0 |
| Complexity | 807 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 3 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
| Publication Number | Title | Priority Date |
|---|---|---|
| JP-2021113176-A | Evaluation method of therapeutic agents for bone tumors and ion channel agonists for the treatment of bone tumors, etc. | 2020-01-20 |
| WO-2021149714-A1 | Agent for treating bone tumor, and method for evaluating ion channel agonist for treatment of bone tumor, etc. | 2020-01-20 |
| US-2020332351-A1 | Methods of associating phenotypical data and single cell sequencing data | 2019-04-19 |
| WO-2020214642-A1 | Methods of associating phenotypical data and single cell sequencing data | 2019-04-19 |
| CN-113557090-A | Precise delivery of ingredients into the fluid | 2019-03-18 |
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