Coumarin 6

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Coumarin 6

Coumarin 6 | CAS 38215-36-0

Catalog Number A17-0001
Category Coumarin
Molecular Formula C20H18N2O2S
Molecular Weight 350.43
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Product Introduction

Coumarin 6 is a fluorescent dye belonging to the coumarin family, known for its intense blue-green fluorescence and high quantum yield. It features a conjugated aromatic system that allows efficient excitation and emission, making it suitable for applications in fluorescence microscopy and flow cytometry. Coumarin 6 is often used in the development of fluorescent probes and as a component in FRET systems, where it functions as a donor molecule due to its favorable spectral properties.

  • Chemical Information

  • Product Specification

  • Application

  • Computed Properties

  • Literatures

  • Patents

Chemical Information

Synonyms Coumarin 540;3-(2-benzothiazolyl)-7-(diethylamino)-2H-1-benzo-pyran-2-one; Coumarin 153; Coumarin 6
Purity ≥99%
IUPAC Name 3-(1,3-benzothiazol-2-yl)-7-(diethylamino)chromen-2-one
SMILES CCN(CC)C1=CC2=C(C=C1)C=C(C(=O)O2)C3=NC4=CC=CC=C4S3
InChI InChI=1S/C20H18N2O2S/c1-3-22(4-2)14-10-9-13-11-15(20(23)24-17(13)12-14)19-21-16-7-5-6-8-18(16)25-19/h5-12H,3-4H2,1-2H3
InChIKey VBVAVBCYMYWNOU-UHFFFAOYSA-N
Solubility soluble in Dimethylformamide,Alcohol
Appearance Light yellow to Brown powder to crystal
Melting Point 208 °C

Product Specification

Storage Keep in dark place.
Signal Warning
GHSHazardStatements H302 (33.33%): Harmful if swallowed [Warning Acute toxicity, oral] H312 (33.33%): Harmful in contact with skin [Warning Acute toxicity, dermal] H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H332 (33.33%): Harmful if inhaled [Warning Acute toxicity, inhalation] H335 (66.67%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
Precautionary Statement Codes P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.)

Application

Computed Properties

XLogP3 4.9
Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 5
Rotatable Bond Count 4
Exact Mass 350.10889899 g/mol
Monoisotopic Mass 350.10889899 g/mol
Topological Polar Surface Area 70.7Ų
Heavy Atom Count 25
Formal Charge 0
Complexity 534
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

Literatures

PMID Publication Date Title Journal
22906968 2012-11-01 A novel luminescent terbium-3-carboxycoumarin probe for time-resolved fluorescence sensing of pesticides methomyl, aldicarb and prometryne Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
22846410 2012-10-15 Preparation and characterization of teniposide PLGA nanoparticles and their uptake in human glioblastoma U87MG cells International journal of pharmaceutics
22369856 2012-06-14 Hepatocellular carcinoma targeting effect of PEGylated liposomes modified with lactoferrin European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
22154100 2012-04-01 Enhanced transdermal delivery of indomethacin using combination of PLGA nanoparticles and iontophoresis in vivo Colloids and surfaces. B, Biointerfaces
22385336 2012-03-29 Stimulus-responsive supramolecular pKa tuning of cucurbit[7]uril encapsulated coumarin 6 dye The journal of physical chemistry. B

Patents

Publication Number Title Priority Date
CN-115227819-A A kind of self-producing oxygen nanoparticles for mediating photodynamic inhibition of skin photoaging and preparation method and application thereof 2022-07-20
CN-115058030-A A kind of preparation method of polymorphic anisotropic semiconducting polymer nanostructure 2022-07-12
CN-114948850-A Preparation method and application of drug-loadable oligopeptide and its soluble layered microneedle 2022-05-26
CN-114832117-A Cell-penetrating peptide-modified nucleic acid-cationic thermosensitive liposome and preparation method thereof 2022-05-20
CN-114831926-A A kind of double-layer microneedle array and preparation method thereof 2022-05-09

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