Coumarin 6 | 38215-36-0

Catelog Number	A17-0001
Category	Coumarin
Molecular Formula	C20H18N2O2S
Molecular Weight	350.43

Catalog Number	Size	Price	Quantity
A17-0001	--	$--

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Product Introduction

Coumarin 6 is a fluorescent dye that has been widely used in cell imaging and flow cytometry due to its excellent photostability. The cell membrane staining capabilities of Coumarin 6 not only facilitate complex visualization of cell morphology but also enable precise assessment of membrane integrity. This dye shows promising applications in drug delivery systems and bioimaging technology, helping to explore a variety of diseases and unravel the mystery of drug efficacy.

Chemical Information
Synonyms	Coumarin 540;3-(2-benzothiazolyl)-7-(diethylamino)-2H-1-benzo-pyran-2-one; Coumarin 153; Coumarin 6
Purity	≥99%
IUPAC Name	3-(1,3-benzothiazol-2-yl)-7-(diethylamino)chromen-2-one
Canonical SMILES	CCN(CC)C1=CC2=C(C=C1)C=C(C(=O)O2)C3=NC4=CC=CC=C4S3
InChI	InChI=1S/C20H18N2O2S/c1-3-22(4-2)14-10-9-13-11-15(20(23)24-17(13)12-14)19-21-16-7-5-6-8-18(16)25-19/h5-12H,3-4H2,1-2H3
InChI Key	VBVAVBCYMYWNOU-UHFFFAOYSA-N
Solubility	soluble in Dimethylformamide,Alcohol
Appearance	Light yellow to Brown powder to crystal
Melting Point	208 °C

Product Specification
Storage	Keep in dark place.
Signal	Warning
GHS Hazard Statements	H302 (33.33%): Harmful if swallowed [Warning Acute toxicity, oral] H312 (33.33%): Harmful in contact with skin [Warning Acute toxicity, dermal] H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H332 (33.33%): Harmful if inhaled [Warning Acute toxicity, inhalation] H335 (66.67%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
Precautionary Statement Codes	P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.)

Computed Properties
XLogP3	4.9
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Exact Mass	350.10889899 g/mol
Monoisotopic Mass	350.10889899 g/mol
Topological Polar Surface Area	70.7Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	534
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Literatures

PMID	Publication Date	Title	Journal
22906968	2012-11-01	A novel luminescent terbium-3-carboxycoumarin probe for time-resolved fluorescence sensing of pesticides methomyl, aldicarb and prometryne	Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
22846410	2012-10-15	Preparation and characterization of teniposide PLGA nanoparticles and their uptake in human glioblastoma U87MG cells	International journal of pharmaceutics
22369856	2012-06-14	Hepatocellular carcinoma targeting effect of PEGylated liposomes modified with lactoferrin	European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
22154100	2012-04-01	Enhanced transdermal delivery of indomethacin using combination of PLGA nanoparticles and iontophoresis in vivo	Colloids and surfaces. B, Biointerfaces
22385336	2012-03-29	Stimulus-responsive supramolecular pKa tuning of cucurbit[7]uril encapsulated coumarin 6 dye	The journal of physical chemistry. B

Patents

Publication Number	Title	Priority Date
CN-115227819-A	A kind of self-producing oxygen nanoparticles for mediating photodynamic inhibition of skin photoaging and preparation method and application thereof	2022-07-20
CN-115058030-A	A kind of preparation method of polymorphic anisotropic semiconducting polymer nanostructure	2022-07-12
CN-114948850-A	Preparation method and application of drug-loadable oligopeptide and its soluble layered microneedle	2022-05-26
CN-114832117-A	Cell-penetrating peptide-modified nucleic acid-cationic thermosensitive liposome and preparation method thereof	2022-05-20
CN-114831926-A	A kind of double-layer microneedle array and preparation method thereof	2022-05-09

Applications of Fluorescent Probes & Dyes

Laser Dye

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Coumarin 6 | 38215-36-0

Product Introduction

Chemical Information

Product Specification

Computed Properties

Literatures

Patents