C6 NBD dihydro Ceramide | 114301-97-2

Catalog Number	A18-0059
Category	Fluorescent Enzyme Substrates
Molecular Formula	C30H51N5O6
Molecular Weight	577.8

Catalog Number	Size	Price	Quantity
A18-0059	--	$--

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Product Introduction

C6 NBD ceramide is a membrane-permeable fluorescent ceramide derivative. C6 NBD ceramide has been used as a fluorescent substrate for UDP-glucose:ceramide glucosyltransferase1 and to demonstrate the translocation of glucocerebroside and sphingomyelin from the Golgi to the plasma membrane.

Chemical Information
Product Specification
Application

Synonyms	N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-sphinganine; C6-NBD Sphinganine; N-C6-NBD-D-erythro-dihydro-Sphingosine
Purity	≥98%
IUPAC Name	N-(1,3-dihydroxyoctadecan-2-yl)-6-[(4-nitro-2,1,3-benzoxadiazol-7-yl)amino]hexanamide
Canonical SMILES	CCCCCCCCCCCCCCCC(C(CO)NC(=O)CCCCCNC1=CC=C(C2=NON=C12)[N+](=O)[O-])O
InChI	InChI=1S/C30H51N5O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-27(37)25(23-36)32-28(38)19-16-14-17-22-31-24-20-21-26(35(39)40)30-29(24)33-41-34-30/h20-21,25,27,31,36-37H,2-19,22-23H2,1H3,(H,32,38)/t25-,27+/m0/s1
InChI Key	GEZLBJRDZRUTOE-AHKZPQOWSA-N
Density	1.1±0.1 g/cm3
Appearance	Solid Powder

Storage

Store at -20°C

C6 NBD dihydro Ceramide is a fluorescent lipid analog used in various biochemical and cell biology applications. Here are some key applications of C6 NBD dihydro Ceramide:

Membrane Trafficking Studies: C6 NBD dihydro Ceramide is employed to study membrane trafficking and lipid distribution within cells. Its fluorescent properties allow researchers to visualize how ceramides are transported and metabolized in cellular compartments. This helps in understanding the mechanisms of lipid transport and their role in cellular physiology.

Sphingolipid Metabolism Research: This compound is used to investigate sphingolipid metabolism as it can be incorporated into cells and tissues to study metabolite transformations. Researchers use C6 NBD dihydro Ceramide to trace the conversion into other sphingolipids, revealing insights into enzymatic pathways and regulatory mechanisms. This knowledge is critical for understanding diseases linked to sphingolipid metabolism, such as Gaucher’s disease and Niemann-Pick disease.

Apoptosis and Cell Death Studies: C6 NBD dihydro Ceramide is utilized in research on apoptosis and programmed cell death. By labeling ceramide molecules, scientists can monitor the role of these lipids in signaling pathways that control cell death. This application is important for exploring therapeutic approaches to modulate apoptosis in diseases such as cancer.

Drug Delivery Systems: In pharmaceutical research, C6 NBD dihydro Ceramide serves as a model compound to study drug delivery and release mechanisms. Its amphiphilic nature makes it suitable for investigating how lipids can be used to encapsulate and deliver therapeutic molecules to target cells. This research contributes to the design of lipid-based drug delivery systems with improved efficiency and specificity.

Applications of Fluorescent Probes & Dyes