
BODIPY FL Prazosin | 175799-93-6
Catalog Number | F01-0162 |
Category | BODIPY |
Molecular Formula | C28H32BF2N7O3 |
Molecular Weight | 563.41 |
Catalog Number | Size | Price | Quantity |
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F01-0162 | -- | $-- |
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Product Introduction
BODIPY FL Prazosin is a green-fluorescent probe for the α1-adrenergic receptor that is used in live cells and flow cytometry.
Chemical Information |
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Synonyms | EverFluor FL Prazosin |
Appearance | Solid Powder |
- Application
BODIPY FL Prazosin is a specialized compound that combines the fluorescent BODIPY (boron-dipyrromethene) dye with prazosin, a selective alpha-1 adrenergic antagonist. The BODIPY FL moiety provides excellent fluorescence properties, such as high brightness and photostability, making it ideal for various imaging and analytical applications. The prazosin component is often used for studying the role of alpha-1 receptors in physiological processes, and the combination of these two entities enables dual functionality for both fluorescence-based assays and receptor-specific studies. This conjugate allows researchers to track prazosin in live systems while simultaneously observing the binding interactions with its target receptor.
One of the key applications of BODIPY FL Prazosin is in fluorescence-based receptor binding studies. The BODIPY FL dye enables high-resolution imaging of prazosin's interactions with alpha-1 adrenergic receptors. Researchers use this compound in live cell imaging and tissue studies to better understand the distribution and localization of these receptors in various biological contexts, such as in cardiovascular research or neuroscience.
Another important application is in drug discovery and development. BODIPY FL Prazosin serves as a powerful tool for screening new compounds that target alpha-1 adrenergic receptors. The fluorescence allows researchers to conduct high-throughput screening (HTS) assays to identify potential drug candidates that can interact with these receptors. This is particularly useful for developing new therapies for conditions such as hypertension, heart failure, and anxiety, where modulation of alpha-1 receptor activity is of therapeutic interest. The ability to visualize and quantify interactions in a rapid and efficient manner accelerates the drug discovery process.
BODIPY FL Prazosin is also used in the study of pharmacokinetics and biodistribution. By conjugating prazosin with a fluorescent dye, researchers can monitor the compound's behavior in vivo, including its absorption, distribution, metabolism, and excretion (ADME). This application is critical for evaluating the pharmacokinetic properties of prazosin and other related compounds. The fluorescence signal allows for real-time tracking of the drug in animal models, aiding in the assessment of how the drug spreads throughout tissues and accumulates in target areas. This data is essential for optimizing drug formulations and improving therapeutic efficacy.
Finally, BODIPY FL Prazosin is used in neurochemical studies, particularly in the investigation of the central nervous system (CNS). The compound’s ability to selectively bind to alpha-1 adrenergic receptors makes it a valuable tool for studying the effects of prazosin in brain tissues. Prazosin is known to have effects on anxiety, stress, and sleep disorders by blocking alpha-1 receptors in the brain, and BODIPY FL Prazosin facilitates studies on these pathways. Using fluorescence techniques, researchers can observe how the compound affects neural signaling, potentially leading to new treatments for psychiatric and neurological disorders.
Applications of Fluorescent Probes & Dyes
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