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BODIPY Fl C5-Ceramide | CAS 133867-53-5
| Catalog Number | F01-0155 |
| Category | BODIPY |
| Molecular Formula | C34H54BN3O3 |
| Molecular Weight | 601.62 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| F01-0155 | 1 mg | $299 | |
| F01-0155 | 10 mg | $899 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
BODIPY Fl C5-Ceramide is a fluorescent probe that features a BODIPY fluorophore conjugated to a C5 ceramide moiety, allowing it to participate in the labeling and imaging of cellular membranes. The compound exhibits distinct excitation and emission properties, enabling its use in fluorescence microscopy to track sphingolipid metabolism and membrane dynamics. Its integration into lipid bilayers and retention within the Golgi apparatus make it a valuable tool for studying intracellular trafficking and lipid signaling pathways.
Chemical Information
Product Specification
Application
Chemical Information
| Synonyms | EverFluor FL C5-Ceramide; N-(4,4-Difluoro-5,7-Dimethyl-4-Bora-3a,4a-Diaza-s-Indacene-3-Pentanoyl)Sphingosine |
| Purity | 97% |
| IUPAC Name | 5-(2,2-difluoro-10,12-dimethyl-1-aza-3-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-3,5,7,9,11-pentaen-4-yl)-N-[(E,2S,3R)-1,3-dihydroxyoctadec-4-en-2-yl]pentanamide |
| SMILES | [B-]1(N2C(=CC(=C2C=C3[N+]1=C(C=C3)CCCCC(=O)N[C@@H](CO)[C@@H](/C=C/CCCCCCCCCCCCC)O)C)C)(F)F |
| InChI | InChI=1S/C34H54BF2N3O3/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-20-33(42)31(26-41)38-34(43)21-18-17-19-29-22-23-30-25-32-27(2)24-28(3)39(32)35(36,37)40(29)30/h16,20,22-25,31,33,41-42H,4-15,17-19,21,26H2,1-3H3,(H,38,43)/b20-16+/t31-,33+/m0/s1 |
| InChIKey | VRQLSQAURNRUHQ-VYPMXFAASA-N |
| Appearance | Brown to Red Solid |
Product Specification
| Excitation | 505 |
| Emission | 511 |
Application
BODIPY Fl C5-Ceramide, a fluorescent lipid analog used extensively in cell biology and imaging, boasts a wide array of applications. Here are four key applications of BODIPY Fl C5-Ceramide.
Cell Membrane Studies: Delving into the intricate world of cell membranes, researchers utilize BODIPY Fl C5-Ceramide to explore their properties and dynamics. Its fluorescence properties enable real-time investigation of lipid composition, lateral movement, and membrane morphology through cutting-edge imaging techniques. This deep dive sheds light on the mechanisms underpinning membrane-associated processes like endocytosis, trafficking, and signal transduction.
Lipid Metabolism Research: Serving as a powerful ally in the realm of lipid metabolism, BODIPY Fl C5-Ceramide acts as a valuable asset for tracking ceramide pathways within cells. By monitoring its conversion into various metabolites, researchers gain profound insights into the roles of ceramide in disease pathways and lipid signaling. This knowledge proves pivotal in unraveling the complexities of lipid metabolism-related conditions such as obesity and diabetes.
Apoptosis and Stress Response Analysis: A stalwart in studying cellular responses to stress and apoptosis, BODIPY Fl C5-Ceramide offers invaluable insights into altered sphingolipid metabolism through its accumulation in cellular compartments. This shift can be monitored through fluorescence microscopy, serving as a vital tool in deciphering the mechanisms governing programmed cell death and identifying potential therapeutic targets for diseases linked to apoptosis.
Drug Delivery and Screening: In the realm of drug delivery research, BODIPY Fl C5-Ceramide takes center stage, enabling the study of lipid-based drug carrier intracellular distribution. Its fluorescent attributes facilitate the visualization of carrier uptake, trafficking, and release within cells, empowering the design of targeted delivery systems and facilitating high-throughput screening of drug candidates affecting ceramide pathways. This application holds immense promise for advancing drug delivery technologies and enhancing therapeutic outcomes.
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