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BODIPY 558/568 C12 | 158757-84-7
| Catalog Number | F01-0161 |
| Category | BODIPY |
| Molecular Formula | C25H31BF2N2O2S |
| Molecular Weight | 472.4 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| F01-0161 | -- | $-- |
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Product Introduction
BODIPY 558/568 C12 is an orange-fluorescent fatty acid that can be used as a building block in the synthesis of various fluorescent phospholipids or other lipophilic probes. It has been used to create bioconjugates with peptides, proteins, modified nucleotides and biopolymers with amine groups using a carbodiimide like EDAC or DIPC.
Chemical Information |
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|---|---|
| Synonyms | 4,4-Difluoro-5-(2-Thienyl)-4-Bora-3a,4a-Diaza-s-Indacene-3-Dodecanoic Acid |
| IUPAC Name | 12-(2,2-difluoro-12-thiophen-2-yl-3-aza-1-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-1(12),4,6,8,10-pentaen-4-yl)dodecanoate;hydron |
| Canonical SMILES | [H+].[B-]1(N2C(=CC=C2CCCCCCCCCCCC(=O)[O-])C=C3[N+]1=C(C=C3)C4=CC=CS4)(F)F |
| InChI | InChI=1S/C25H31BF2N2O2S/c27-26(28)29-20(11-8-6-4-2-1-3-5-7-9-13-25(31)32)14-15-21(29)19-22-16-17-23(30(22)26)24-12-10-18-33-24/h10,12,14-19H,1-9,11,13H2,(H,31,32) |
| InChI Key | PHUIDILRCYWCMI-UHFFFAOYSA-N |
| Appearance | Solid Powder |
- Application
BODIPY 558/568 C12, a versatile fluorescent lipid probe, is widely utilized in biological and biochemical research for lipid imaging and tracking. Here are four key applications of BODIPY 558/568 C12:
Lipid Trafficking Studies: Delving into the intricate dynamics of lipid movements within cells, researchers employ BODIPY 558/568 C12 to gain insights into the transport pathways of lipids. By integrating this fluorescent probe into lipid molecules, scientists reveal the hidden journey of lipids within cells, shedding light on lipid metabolism, distribution, and their crucial role in processes like membrane formation and signaling.
Membrane Dynamics: At the forefront of cell biology, BODIPY 558/568 C12 serves as a vital tool for exploring the behavior and composition of cellular membranes. Its fluorescence properties enable researchers to track changes in membrane structure, fluidity, and organization in response to various stimuli or treatments. This valuable information plays a pivotal role in unraveling the functions associated with membranes and understanding disorders stemming from membrane abnormalities.
Live Cell Imaging: Renowned for its exceptional photostability and vibrant fluorescence, BODIPY 558/568 C12 finds its niche in live cell imaging applications. Scientists leverage its capabilities to examine the spatial and temporal distribution of lipids within living cells seamlessly without disrupting cellular activities. This real-time imaging prowess supports investigations into lipid-related signal transduction and cellular transformations, offering critical insights into dynamic cellular processes.
Lipid Metabolism Research: A cornerstone in metabolic studies, BODIPY 558/568 C12 is instrumental in tracing lipid incorporation and modifications across various biological systems. By labeling with BODIPY 558/568 C12, researchers track the uptake and assimilation of fatty acids in cells, unraveling metabolic pathways and energy equilibrium.
Computed Properties | |
|---|---|
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 12 |
| Exact Mass | 472.2167359 g/mol |
| Monoisotopic Mass | 472.2167359 g/mol |
| Topological Polar Surface Area | 76.3Ų |
| Heavy Atom Count | 33 |
| Formal Charge | 0 |
| Complexity | 796 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 2 |
| Compound Is Canonicalized | Yes |
Applications of Fluorescent Probes & Dyes
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