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BAPTA Tetrasodium salt | 126824-24-6
| Catalog Number | A14-0067 |
| Category | Calcium, Chloride Indictors and Other indicators |
| Molecular Formula | C22H20N2Na4O10 |
| Molecular Weight | 564.37 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| A14-0067 | -- | $-- |
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Product Introduction
BAPTA Tetrasodium salt is a membrane-impermeant metal chelator BAPTA, which has selectivity for Ca2+ ions. BAPTA Tetrasodium salt has been used to buffer Ca2+ for investigations of the role of cytosolic Ca2+.
Chemical Information |
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| Synonyms | BAPTA Tetrasodium; Sodium 2,2',2'',2'''-(((ethane-1,2-diylbis(oxy))bis(2,1-phenylene))bis(azanetriyl))tetraacetate |
| Canonical SMILES | C1=CC=C(C(=C1)N(CC(=O)[O-])CC(=O)[O-])OCCOC2=CC=CC=C2N(CC(=O)[O-])CC(=O)[O-].[Na+].[Na+].[Na+].[Na+] |
| InChI | InChI=1S/C22H24N2O10.4Na/c25-19(26)11-23(12-20(27)28)15-5-1-3-7-17(15)33-9-10-34-18-8-4-2-6-16(18)24(13-21(29)30)14-22(31)32;;;;/h1-8H,9-14H2,(H,25,26)(H,27,28)(H,29,30)(H,31,32);;;;/q;4*+1/p-4 |
| InChI Key | ZWSMLJACYSGFKD-UHFFFAOYSA-J |
| Appearance | Solid Powder |
- Product Specification
- Application
| Excitation | 433 |
| Emission | 545 ±10 |
BAPTA Tetrasodium salt, a calcium chelator with diverse applications in bioscience research, offers insights into the complexities of cellular functions. Here are four key applications:
Calcium Signaling Studies: Within the realm of cell biology, BAPTA Tetrasodium salt plays a pivotal role in scrutinizing intracellular calcium dynamics by chelating calcium ions. Through this process, researchers gain a deep understanding of calcium’s involvement in diverse cellular processes ranging from muscle contraction to neurotransmitter release and signal transduction. This knowledge is fundamental for unraveling the intricate web of calcium-mediated cellular functions.
Neurobiology: At the forefront of neurobiological research, BAPTA Tetrasodium salt serves as a valuable tool for exploring the impact of calcium on neuronal activity and brain function. Scientists leverage this chelator to manipulate intracellular calcium levels, examining its effects on synaptic transmission, plasticity, and neurodegeneration. Such investigations contribute to the development of innovative therapeutic strategies for addressing neurological disorders.
Electrophysiology: In the realm of electrophysiological experiments, BAPTA Tetrasodium salt is instrumental in controlling calcium-dependent ionic currents. By buffering intracellular calcium levels, researchers can isolate and analyze specific ion channels, shedding light on their roles in membrane potentials and action potentials. This profound understanding of the electrochemical basis of cellular excitability is essential for advancing our knowledge of cellular function.
Cell Physiology: Exploring the intricacies of cell physiology, BAPTA Tetrasodium salt facilitates the examination of calcium’s impact on cellular motility, proliferation, and apoptosis. Through precise management of intracellular calcium levels, researchers can unravel the intricate pathways through which calcium signals influence cell behavior. This knowledge lays the groundwork for identifying potential therapeutic targets in diseases characterized by dysregulated calcium signaling.
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