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Ac-YVAD-AFC | 219137-85-6
| Catelog Number | A18-0005 |
| Category | Fluorescent Enzyme Substrates |
| Molecular Formula | C33H36F3N5O10 |
| Molecular Weight | 719.66 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| A18-0005 | -- | $-- |
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Product Introduction
Ac-YVAD-AFC is a fluorogenic substrate for caspase-1 and caspase-4. Caspase activity can be quantified by fluorescent detection of free AFC (7-amino-4-trifluoromethylcoumarin), which is excited at 400 nm and emits at 505 nm.
Chemical Information |
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|---|---|
| Synonyms | Caspase-1 Substrate VI (Fluorogenic); Ac-Tyr-Val-Ala-Asp-7-amino-4-Trifluoromethlcoumarin; N-acetyl-L-tyrosyl-L-valyl-L-alanyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-L-α-asparagine |
| Purity | ≥95% |
| IUPAC Name | (3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-4-oxo-4-[[2-oxo-4-(trifluoromethyl)chromen-7-yl]amino]butanoic acid |
| Canonical SMILES | CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)O)C(=O)NC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)C |
| InChI | InChI=1S/C33H36F3N5O10/c1-15(2)28(41-31(49)23(38-17(4)42)11-18-5-8-20(43)9-6-18)32(50)37-16(3)29(47)40-24(14-26(44)45)30(48)39-19-7-10-21-22(33(34,35)36)13-27(46)51-25(21)12-19/h5-10,12-13,15-16,23-24,28,43H,11,14H2,1-4H3,(H,37,50)(H,38,42)(H,39,48)(H,40,47)(H,41,49)(H,44,45)/t16-,23-,24-,28-/m0/s1 |
| InChI Key | GWKJISJKNKIJNP-DEQDFGQZSA-N |
| Solubility | Soluble in DMSO (Slightly), Methanol (Silghtly) |
| Density | 1.42 g/cm3 |
| Appearance | Off-White to Pale Beige Solid |
| Boiling Point | 1084.64°C at 760 mmHg |
| Melting Point | >190°C (dec.) |
Product Specification |
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|---|---|
| Excitation | 400 nm |
| Emission | 505 nm |
| Storage | Store at -20°C |
Computed Properties | |
|---|---|
| XLogP3 | 1.8 |
| Hydrogen Bond Donor Count | 7 |
| Hydrogen Bond Acceptor Count | 13 |
| Rotatable Bond Count | 14 |
| Exact Mass | 719.24142685 g/mol |
| Monoisotopic Mass | 719.24142685 g/mol |
| Topological Polar Surface Area | 229Ų |
| Heavy Atom Count | 51 |
| Formal Charge | 0 |
| Complexity | 1360 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 4 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| US-2014309247-A1 | Systems And Methods For Detecting Scalp Follicular Inflammation In Humans | 2013-04-15 |
| US-2013096050-A1 | Highly active polypeptides and methods of making and using the same | 2010-04-22 |
| US-2018193422-A1 | Highly active polypeptides and methods of making and using the same | 2010-04-22 |
| US-9782454-B2 | Highly active polypeptides and methods of making and using the same | 2010-04-22 |
| US-10772934-B2 | Highly active polypeptides and methods of making and using the same | 2010-04-22 |
Applications of Fluorescent Probes & Dyes
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