Ac-WLA-AMC

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Ac-WLA-AMC

Ac-WLA-AMC | 1104011-59-7

Catalog Number A18-0050
Category Fluorescent Enzyme Substrates
Molecular Formula C32H37N5O6
Molecular Weight 587.7
Catalog Number Size Price Quantity
A18-0050 -- $--

Product Introduction

Ac-WLA-AMC is a fluorogenic substrate for the β5c subunit of the 20S proteasome. Ac-WLA-AMC is cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the β5c subunit activity.

Chemical Information

Synonyms Acetyl-Trp-Leu-Ala-7-amino-4-Methylcoumarin; N-acetyl-L-tryptophyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-alaninamide
Purity ≥95%
IUPAC Name (2S)-2-[[(2S)-2-acetamido-3-(1H-indol-3-yl)propanoyl]amino]-4-methyl-N-[(2S)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopropan-2-yl]pentanamide
Canonical SMILES CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C
InChI InChI=1S/C32H37N5O6/c1-17(2)12-26(37-32(42)27(35-20(5)38)14-21-16-33-25-9-7-6-8-24(21)25)31(41)34-19(4)30(40)36-22-10-11-23-18(3)13-29(39)43-28(23)15-22/h6-11,13,15-17,19,26-27,33H,12,14H2,1-5H3,(H,34,41)(H,35,38)(H,36,40)(H,37,42)/t19-,26-,27-/m0/s1
InChI Key PIJMRHCPKXLMIS-DOYMOWJKSA-N
Appearance Solid Powder
  • Product Specification
Excitation 351 nm
Emission 430 nm
Storage Store at -20°C

Computed Properties

XLogP3 3.3
Hydrogen Bond Donor Count 5
Hydrogen Bond Acceptor Count 6
Rotatable Bond Count 11
Exact Mass 587.27438392 g/mol
Monoisotopic Mass 587.27438392 g/mol
Topological Polar Surface Area 159Ų
Heavy Atom Count 43
Formal Charge 0
Complexity 1090
Isotope Atom Count 0
Defined Atom Stereocenter Count 3
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes
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