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Ac-VEID-AMC | 219137-97-0
| Catelog Number | A18-0011 |
| Category | Fluorescent Enzyme Substrates |
| Molecular Formula | C32H43N5O11 |
| Molecular Weight | 673.7 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| A18-0011 | -- | $-- |
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Product Introduction
Ac-VEID-AMC is a fluorogenic substrate for caspase-6 and related proteases including caspase-8. Caspase activity can be quantified by fluorescent detection of free AMC (7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm.
Chemical Information |
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|---|---|
| Synonyms | N-Acetyl-Val-Glu-Ile-Asp-7-amido-4-Methylcoumarin; N-acetyl-L-valyl-L-α-glutamyl-L-isoleucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-α-asparagine |
| Purity | ≥95% |
| IUPAC Name | (4S)-4-[[(2S)-2-acetamido-3-methylbutanoyl]amino]-5-[[(2S,3S)-1-[[(2S)-3-carboxy-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid |
| Canonical SMILES | CCC(C)C(C(=O)NC(CC(=O)O)C(=O)NC1=CC2=C(C=C1)C(=CC(=O)O2)C)NC(=O)C(CCC(=O)O)NC(=O)C(C(C)C)NC(=O)C |
| InChI | InChI=1S/C32H43N5O11/c1-7-16(4)28(37-29(44)21(10-11-24(39)40)35-31(46)27(15(2)3)33-18(6)38)32(47)36-22(14-25(41)42)30(45)34-19-8-9-20-17(5)12-26(43)48-23(20)13-19/h8-9,12-13,15-16,21-22,27-28H,7,10-11,14H2,1-6H3,(H,33,38)(H,34,45)(H,35,46)(H,36,47)(H,37,44)(H,39,40)(H,41,42)/t16-,21-,22-,27-,28-/m0/s1 |
| InChI Key | QMXIJZDGCJEANV-YPBMFZGESA-N |
| Appearance | Solid Powder |
Product Specification |
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|---|---|
| Excitation | 340-360 nm |
| Emission | 440-460 nm |
| Storage | Store at -20°C |
Computed Properties | |
|---|---|
| XLogP3 | 0.9 |
| Hydrogen Bond Donor Count | 7 |
| Hydrogen Bond Acceptor Count | 11 |
| Rotatable Bond Count | 17 |
| Exact Mass | 673.29590720 g/mol |
| Monoisotopic Mass | 673.29590720 g/mol |
| Topological Polar Surface Area | 246Ų |
| Heavy Atom Count | 48 |
| Formal Charge | 0 |
| Complexity | 1280 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 5 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| US-2013096050-A1 | Highly active polypeptides and methods of making and using the same | 2010-04-22 |
| US-2018193422-A1 | Highly active polypeptides and methods of making and using the same | 2010-04-22 |
| US-9782454-B2 | Highly active polypeptides and methods of making and using the same | 2010-04-22 |
| US-10772934-B2 | Highly active polypeptides and methods of making and using the same | 2010-04-22 |
| US-2021205415-A1 | Highly active polypeptides and methods of making and using the same | 2010-04-22 |
Applications of Fluorescent Probes & Dyes
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