Ac-VEID-AMC | 219137-97-0
Catelog Number | A18-0011 |
Category | Fluorescent Enzyme Substrates |
Molecular Formula | C32H43N5O11 |
Molecular Weight | 673.7 |
Catalog Number | Size | Price | Quantity |
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A18-0011 | -- | $-- |
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Product Introduction
Ac-VEID-AMC is a fluorogenic substrate for caspase-6 and related proteases including caspase-8. Caspase activity can be quantified by fluorescent detection of free AMC (7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm.
Chemical Information |
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Synonyms | N-Acetyl-Val-Glu-Ile-Asp-7-amido-4-Methylcoumarin; N-acetyl-L-valyl-L-α-glutamyl-L-isoleucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-α-asparagine |
Purity | ≥95% |
IUPAC Name | (4S)-4-[[(2S)-2-acetamido-3-methylbutanoyl]amino]-5-[[(2S,3S)-1-[[(2S)-3-carboxy-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid |
Canonical SMILES | CCC(C)C(C(=O)NC(CC(=O)O)C(=O)NC1=CC2=C(C=C1)C(=CC(=O)O2)C)NC(=O)C(CCC(=O)O)NC(=O)C(C(C)C)NC(=O)C |
InChI | InChI=1S/C32H43N5O11/c1-7-16(4)28(37-29(44)21(10-11-24(39)40)35-31(46)27(15(2)3)33-18(6)38)32(47)36-22(14-25(41)42)30(45)34-19-8-9-20-17(5)12-26(43)48-23(20)13-19/h8-9,12-13,15-16,21-22,27-28H,7,10-11,14H2,1-6H3,(H,33,38)(H,34,45)(H,35,46)(H,36,47)(H,37,44)(H,39,40)(H,41,42)/t16-,21-,22-,27-,28-/m0/s1 |
InChI Key | QMXIJZDGCJEANV-YPBMFZGESA-N |
Appearance | Solid Powder |
Product Specification |
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Excitation | 340-360 nm |
Emission | 440-460 nm |
Storage | Store at -20°C |
Computed Properties | |
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XLogP3 | 0.9 |
Hydrogen Bond Donor Count | 7 |
Hydrogen Bond Acceptor Count | 11 |
Rotatable Bond Count | 17 |
Exact Mass | 673.29590720 g/mol |
Monoisotopic Mass | 673.29590720 g/mol |
Topological Polar Surface Area | 246Ų |
Heavy Atom Count | 48 |
Formal Charge | 0 |
Complexity | 1280 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 5 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently-Bonded Unit Count | 1 |
Compound Is Canonicalized | Yes |
Patents
Publication Number | Title | Priority Date |
---|---|---|
US-2013096050-A1 | Highly active polypeptides and methods of making and using the same | 2010-04-22 |
US-2018193422-A1 | Highly active polypeptides and methods of making and using the same | 2010-04-22 |
US-9782454-B2 | Highly active polypeptides and methods of making and using the same | 2010-04-22 |
US-10772934-B2 | Highly active polypeptides and methods of making and using the same | 2010-04-22 |
US-2021205415-A1 | Highly active polypeptides and methods of making and using the same | 2010-04-22 |
Applications of Fluorescent Probes & Dyes
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