Ac-PAL-AMC | 1431362-79-6

Catalog Number	A18-0053
Category	Fluorescent Enzyme Substrates
Molecular Formula	C26H34N4O6
Molecular Weight	498.6

Catalog Number	Size	Price	Quantity
A18-0053	--	$--

inquiry

Worldwide Delivery
Quality Assurance
24/7 Customer Service

Product Introduction

Ac-PAL-AMC is a fluorogenic substrate for the β1i/LMP2 subunit of the 20S immunoproteasome. It can be cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the activity of the β1i/LMP2 subunit of the 20S immunoproteasome.

Chemical Information
Synonyms	Acetyl-Pro-Ala-Leu-7-amino-4-Methylcoumarin; 1-acetyl-L-prolyl-L-alanyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-leucinamide
Purity	≥95%
IUPAC Name	(2S)-1-acetyl-N-[(2S)-1-[[(2S)-4-methyl-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
Canonical SMILES	CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C3CCCN3C(=O)C
InChI	InChI=1S/C26H34N4O6/c1-14(2)11-20(25(34)28-18-8-9-19-15(3)12-23(32)36-22(19)13-18)29-24(33)16(4)27-26(35)21-7-6-10-30(21)17(5)31/h8-9,12-14,16,20-21H,6-7,10-11H2,1-5H3,(H,27,35)(H,28,34)(H,29,33)/t16-,20-,21-/m0/s1
InChI Key	BWJPVHDZSJFFDM-NDXORKPFSA-N
Appearance	Solid Powder

Product Specification

Excitation	351 nm
Emission	430 nm
Storage	Store at -20°C

Computed Properties
XLogP3	1.9
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	8
Exact Mass	498.24783482 g/mol
Monoisotopic Mass	498.24783482 g/mol
Topological Polar Surface Area	134Å²
Heavy Atom Count	36
Formal Charge	0
Complexity	916
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Applications of Fluorescent Probes & Dyes

Laser Dye

Get More Product Details?

Ac-PAL-AMC | 1431362-79-6

Product Introduction

Chemical Information

Computed Properties