Ac-IETD-AFC | 211990-57-7
Catelog Number | A18-0006 |
Category | Fluorescent Enzyme Substrates |
Molecular Formula | C31H38F3N5O12 |
Molecular Weight | 729.7 |
Catalog Number | Size | Price | Quantity |
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A18-0006 | -- | $-- |
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Product Introduction
Ac-IETD-AFC is a fluorogenic substrate for caspase-8 and caspase-3. Caspase activity can be quantified by fluorescent detection of free AFC (7-amino-4-trifluoromethylcoumarin), which is excited at 400 nm and emits at 505 nm.
Chemical Information |
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Synonyms | N-Acetyl-Ile-Glu-Thr-Asp-7-amino-4-Trifluoromethylcoumarin; N-acetyl-L-isoleucyl-L-α-glutamyl-L-threonyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-L-α-asparagine |
Purity | ≥95% |
Canonical SMILES | CCC(C)C(C(=O)NC(CCC(=O)O)C(=O)NC(C(C)O)C(=O)NC(CC(=O)O)C(=O)NC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F)NC(=O)C |
InChI | InChI=1S/C31H38F3N5O12/c1-5-13(2)25(35-15(4)41)29(49)37-19(8-9-22(42)43)27(47)39-26(14(3)40)30(50)38-20(12-23(44)45)28(48)36-16-6-7-17-18(31(32,33)34)11-24(46)51-21(17)10-16/h6-7,10-11,13-14,19-20,25-26,40H,5,8-9,12H2,1-4H3,(H,35,41)(H,36,48)(H,37,49)(H,38,50)(H,39,47)(H,42,43)(H,44,45)/t13-,14+,19-,20-,25-,26-/m0/s1 |
InChI Key | CGUOWXRXLQXOKO-BYLHTXFJSA-N |
Appearance | Solid Powder |
Product Specification |
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Excitation | 400 nm |
Emission | 505 nm |
Storage | Store at -20°C |
Applications of Fluorescent Probes & Dyes
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