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Ac-DNLD-AMC | 958001-92-8
| Catelog Number | A18-0040 |
| Category | Fluorescent Enzyme Substrates |
| Molecular Formula | C30H38N6O12 |
| Molecular Weight | 674.7 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| A18-0040 | -- | $-- |
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Product Introduction
Ac-DNLD-AMC is a fluorogenic substrate for caspase-3. It is cleaved by caspase-3 to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify caspase-3 activity.
Chemical Information |
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|---|---|
| Synonyms | N-Acetyl-Asp-Asn-Leu-Asp-7-amido-Methylcoumarin; N-acetyl-L-α-aspartyl-L-asparaginyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-α-asparagine |
| Purity | ≥95% |
| IUPAC Name | (3S)-3-acetamido-4-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-3-carboxy-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-4-oxobutanoic acid |
| Canonical SMILES | CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)C(CC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(CC(=O)N)NC(=O)C(CC(=O)O)NC(=O)C |
| InChI | InChI=1S/C30H38N6O12/c1-13(2)7-18(34-29(46)19(10-23(31)38)35-30(47)20(11-24(39)40)32-15(4)37)28(45)36-21(12-25(41)42)27(44)33-16-5-6-17-14(3)8-26(43)48-22(17)9-16/h5-6,8-9,13,18-21H,7,10-12H2,1-4H3,(H2,31,38)(H,32,37)(H,33,44)(H,34,46)(H,35,47)(H,36,45)(H,39,40)(H,41,42)/t18-,19-,20-,21-/m0/s1 |
| InChI Key | IBRRXVTUFUKLDZ-TUFLPTIASA-N |
Product Specification |
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|---|---|
| Storage | Store at -20°C |
Computed Properties | |
|---|---|
| XLogP3 | -1.9 |
| Hydrogen Bond Donor Count | 8 |
| Hydrogen Bond Acceptor Count | 12 |
| Rotatable Bond Count | 17 |
| Exact Mass | 674.25477067 g/mol |
| Monoisotopic Mass | 674.25477067 g/mol |
| Topological Polar Surface Area | 290Ų |
| Heavy Atom Count | 48 |
| Formal Charge | 0 |
| Complexity | 1330 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 4 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Applications of Fluorescent Probes & Dyes
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