Ac-DEVD-AMC | 169332-61-0

Catelog Number	A18-0013
Category	Fluorescent Enzyme Substrates
Molecular Formula	C30H37N5O13
Molecular Weight	675.64

Catalog Number	Size	Price	Quantity
A18-0013	--	$--

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Product Introduction

Ac-DEVD-AMC is a fluorogenic substrate for caspase-3. Caspase activity can be quantified by fluorescent detection of free AMC (7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm.

Chemical Information
Synonyms	N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-Methylcoumarin; N-acetyl-L-α-aspartyl-L-α-glutamyl-L-valyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-α-asparagine
Purity	≥95%
IUPAC Name	(4S)-4-[[(2S)-2-acetamido-3-carboxypropanoyl]amino]-5-[[(2S)-1-[[(2S)-3-carboxy-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-oxopentanoic acid
Canonical SMILES	CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)C(CC(=O)O)NC(=O)C(C(C)C)NC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C
InChI	InChI=1S/C30H37N5O13/c1-13(2)26(35-27(44)18(7-8-22(37)38)33-29(46)19(11-23(39)40)31-15(4)36)30(47)34-20(12-24(41)42)28(45)32-16-5-6-17-14(3)9-25(43)48-21(17)10-16/h5-6,9-10,13,18-20,26H,7-8,11-12H2,1-4H3,(H,31,36)(H,32,45)(H,33,46)(H,34,47)(H,35,44)(H,37,38)(H,39,40)(H,41,42)/t18-,19-,20-,26-/m0/s1
InChI Key	ALZSTTDFHZHSCA-RNVDEAKXSA-N
Density	1.423±0.06 g/cm3
Boiling Point	1200.1±65.0 °C at 760 mmHg

Product Specification
Excitation	340-360 nm
Emission	440-460 nm
Storage	Store at -20°C

Computed Properties
XLogP3	-1.3
Hydrogen Bond Donor Count	8
Hydrogen Bond Acceptor Count	13
Rotatable Bond Count	17
Exact Mass	675.23878625 g/mol
Monoisotopic Mass	675.23878625 g/mol
Topological Polar Surface Area	284Å²
Heavy Atom Count	48
Formal Charge	0
Complexity	1330
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Literatures

PMID	Publication Date	Title	Journal
25446497	2014-12-05	Isolation and prevention of calcium oxalate-induced apoptotic death and oxidative stress in MDCK cells by diosgenin	Chemico-biological interactions
19364322	2009-03-01	A secreted caspase-3-substrate-cleaving activity at low pH belongs to cathepsin B: a study on primary brain cell cultures	Biochemistry. Biokhimiia
18393770	2008-03-01	Brain cathepsin B cleaves a caspase substrate	Biochemistry. Biokhimiia
17678535	2007-08-01	PepBank--a database of peptides based on sequence text mining and public peptide data sources	BMC bioinformatics
16517063	2007-01-08	Bis(2-hydroxybenzylidene)acetone, a potent inducer of the phase 2 response, causes apoptosis in mouse leukemia cells through a p53-independent, caspase-mediated pathway	Cancer letters

Patents

Publication Number	Title	Priority Date
EP-3929209-A1	Vasopressin-2 receptor antagonist peptides and uses thereof	2020-06-24
KR-20220158727-A	Methods for enriching and expanding tumor-reactive T cells ex vivo and compositions related thereto	2020-02-27
WO-2021127187-A1	Rna nanoparticle for liver cancer treatment	2019-12-20
US-2022372493-A1	Rna nanoparticle for liver cancer treatment	2019-12-20
JP-2023504042-A	Methods of generating tumor-reactive T-cell compositions using modulators	2019-11-27

Applications of Fluorescent Probes & Dyes

Laser Dye

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Ac-DEVD-AMC | 169332-61-0

Product Introduction

Chemical Information

Product Specification

Computed Properties

Literatures

Patents