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Ac-DEVD-AFC | 201608-14-2
| Catelog Number | A18-0003 |
| Category | Fluorescent Enzyme Substrates |
| Molecular Formula | C30H34F3N5O13 |
| Molecular Weight | 729.61 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| A18-0003 | -- | $-- |
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Product Introduction
Ac-DEVD-AFC is a fluorogenic substrate for caspase-3 and related caspases. Caspase activity can be quantified by fluorescent detection of free AFC (7-amino-4-trifluoromethylcoumarin), which is excited at 400 nm and emits at 505 nm.
Chemical Information |
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| Synonyms | Ac-DEVD-7-amido-4-trifluoroMethylcoumarin; Caspase-3 Substrate Ⅶ, Fluorogenic; Ac-Asp-Glu-Val-Asp-AFC; N-acetyl-L-α-aspartyl-L-α-glutamyl-L-valyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-L-α-asparagine |
| Purity | ≥90% |
| IUPAC Name | (4S)-4-[[(2S)-2-acetamido-3-carboxypropanoyl]amino]-5-[[(2S)-1-[[(2S)-3-carboxy-1-oxo-1-[[2-oxo-4-(trifluoromethyl)chromen-7-yl]amino]propan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-oxopentanoic acid |
| Canonical SMILES | CC(C)C(C(=O)NC(CC(=O)O)C(=O)NC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F)NC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C |
| InChI | InChI=1S/C30H34F3N5O13/c1-12(2)25(38-26(47)17(6-7-21(40)41)36-28(49)18(10-22(42)43)34-13(3)39)29(50)37-19(11-23(44)45)27(48)35-14-4-5-15-16(30(31,32)33)9-24(46)51-20(15)8-14/h4-5,8-9,12,17-19,25H,6-7,10-11H2,1-3H3,(H,34,39)(H,35,48)(H,36,49)(H,37,50)(H,38,47)(H,40,41)(H,42,43)(H,44,45)/t17-,18-,19-,25-/m0/s1 |
| InChI Key | GZDRODOYEFEHGG-NUDCOPPTSA-N |
| Solubility | Soluble in Water |
| Density | 1.495±0.06 g/cm3 (Predicted) |
| Appearance | White Powder |
| Boiling Point | 1152.7±65.0°C (Predicted) |
Product Specification |
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| Excitation | 400 nm |
| Emission | 505 nm |
| Storage | Store at -20°C |
Applications of Fluorescent Probes & Dyes
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