NHS-Ac-N3 | CAS 824426-32-6

Name: NHS-Ac-N3
Brand: BOC Sciences
Rating: 5 (1 reviews)

Catalog Number	R14-0325
Category	Azides
Molecular Formula	C6H6N4O4
Molecular Weight	198.13

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Product Introduction

NHS-Ac-N3 is a paramount reagent within biomedicine and emerges as an exquisite modulator for drug advancement and biomolecule conjugation. This compound has unique chemical properties that play a key role in the fusion of multiple drugs and bioconjugates, aiding in the development of effective treatments for diseases such as cancer, neurodegenerative diseases, and infectious diseases.

Chemical Information
Product Specification
Application
QC Data

Synonyms	Azidoacetic acid NHS ester;(2,5-Dioxopyrrolidin-1-yl) 2-azidoacetate;
Purity	≥98%
IUPAC Name	(2,5-dioxopyrrolidin-1-yl) 2-azidoacetate
Canonical SMILES	C1CC(=O)N(C1=O)OC(=O)CN=[N+]=[N-]
InChI	InChI=1S/C6H6N4O4/c7-9-8-3-6(13)14-10-4(11)1-2-5(10)12/h1-3H2
InChIKey	FENNDBOWHRZLTQ-UHFFFAOYSA-N
Appearance	White crystalline powder

Storage

Store at-20 °C

NHS-Ac-N3, a versatile chemical compound utilized in diverse bioconjugation and labeling applications, showcases its adaptability across various scientific endeavors. Here are four key applications of NHS-Ac-N3:

Protein Labeling: A common practice in the realm of protein research, NHS-Ac-N3 serves as a pivotal tool for labeling proteins with azide groups, enabling subsequent modifications through click chemistry. This strategy allows researchers to delve into protein interactions and cellular localization, shedding light on the intricacies of protein function and dynamics within biological systems.

Drug Delivery System Development: At the forefront of pharmaceutical innovation, NHS-Ac-N3 plays a critical role in crafting targeted drug delivery systems. By conjugating drug molecules or carriers with azide groups, researchers can attach specific targeting ligands via click chemistry, enhancing drug efficacy and minimizing off-target effects.

Biomolecule Synthesis: Empowering researchers in the synthesis of complex biomolecules, NHS-Ac-N3 enables site-specific modifications through the incorporation of reactive azide groups into nucleic acids, peptides, and other biomolecules. This level of precision offers unparalleled control over molecular assembly, fostering the engineering of novel biomolecular structures with targeted functionalities.

Bioconjugation: A cornerstone in the field of diagnostics and therapeutics, NHS-Ac-N3 emerges as an indispensable reagent for bioconjugation techniques. By facilitating the attachment of various biomolecules to surfaces or nanoparticles, this compound enhances detection sensitivity and therapeutic properties. The resulting bioconjugates play a pivotal role in the development of cutting-edge diagnostic assays and targeted therapeutic interventions, driving forward the frontier of biotechnological advancements.

HNMR