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Lucigenin | CAS 2315-97-1
| Catalog Number | A16-0012 |
| Category | Other Cell Fluorescent Probes |
| Molecular Formula | C28H22N2.2NO3 |
| Molecular Weight | 510.50 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Lucigenin is a fluoerscent probe that exhibits a bluish-green fluorescence in the presence of superoxide and chloride. It can be used to detect superoxide production by enzymatic and cellular sources.
Chemical Information
Product Specification
Application
Computed Properties
Patents
| Related CAS | 22103-92-0 (free base) |
| Synonyms | 10,10'-dimethyl-9,9'-biacridinium, dinitrate; N,N'-Dimethyl-9,9'-biacridinium dinitrate; Lucigenin Nitrate; NSC 151912; Bis(N-methylacridinium) Nitrate; 9,9'-Bis(N-methylacridinium nitrate) |
| Purity | ≥95% |
| IUPAC Name | 10-methyl-9-(10-methylacridin-10-ium-9-yl)acridin-10-ium;dinitrate |
| Canonical SMILES | C[N+]1=C2C=CC=CC2=C(C3=CC=CC=C31)C4=C5C=CC=CC5=[N+](C6=CC=CC=C64)C.[N+](=O)([O-])[O-].[N+](=O)([O-])[O-] |
| InChI | InChI=1S/C28H22N2.2NO3/c1-29-23-15-7-3-11-19(23)27(20-12-4-8-16-24(20)29)28-21-13-5-9-17-25(21)30(2)26-18-10-6-14-22(26)28;2*2-1(3)4/h3-18H,1-2H3;;/q+2;2*-1 |
| InChIKey | KNJDBYZZKAZQNG-UHFFFAOYSA-N |
| Solubility | Soluble in Acetic Acid |
| Appearance | Reddish-brown Powder |
| Excitation | 455 nm |
| Emission | 505 nm |
| Storage | -20°C |
| Signal | Danger |
| GHSHazardStatements | H272 (100%): May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids] H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] |
| Precautionary Statement Codes | P210, P220, P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, P362+P364, P370+P378, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.) |
Lucigenin, a versatile chemical compound central to bioluminescence-based applications, finds diverse utility across various fields. Here are four key applications of Lucigenin:
Reactive Oxygen Species (ROS) Detection: Lucigenin emerges as a beacon in the realm of chemistry, serving as a luminous probe to unveil reactive oxygen species like superoxide anions in biological specimens. Researchers employ Lucigenin to scrutinize oxidative stress levels in cells and tissues, illuminating pathways linked to inflammation, aging, and a spectrum of oxidative stress-related maladies.
Cardiovascular Research: Within the corridors of cardiovascular research, Lucigenin stands tall as an instrument for probing endothelial dynamics and vascular vigor. It finds resonance in assays gauging superoxide production in blood vessels, shedding light on the molecular orchestrations underpinning hypertension, atherosclerosis, and other cardiovascular afflictions.
Environmental Monitoring: Lucigenin, with its luminescent prowess, plays a pivotal role in surveilling our ecosystems. From water to soil, Lucigenin-based assays detect and quantify pollutants and toxins, unveiling the oxidative reverberations provoked by environmental contaminants. This sensitivity, etched in its luminous glow, aids in gauging environmental well-being and identifying potential hazards lurking in the shadows.
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 1 |
| Exact Mass | 510.15393443 g/mol |
| Monoisotopic Mass | 510.15393443 g/mol |
| Topological Polar Surface Area | 134Ų |
| Heavy Atom Count | 38 |
| Formal Charge | 0 |
| Complexity | 522 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 3 |
| Compound Is Canonicalized | Yes |
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-115128062-A | Method and use for detecting freshness of food | 2022-08-29 |
| CN-115128062-B | Method and application of detecting grain freshness | 2022-08-29 |
| CN-115112907-A | A kind of vitamin B12 quantitative detection kit and its application | 2022-07-28 |
| CN-115166264-A | A kind of hepcidin detection kit and preparation method thereof | 2022-06-30 |
| CN-114994338-A | A kind of follicle-stimulating hormone detection kit and preparation method and application thereof | 2022-05-26 |
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