Lucigenin

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Lucigenin

Lucigenin | 2315-97-1

Catalog Number A16-0012
Category Other Cell Fluorescent Probes
Molecular Formula C28H22N2.2NO3
Molecular Weight 510.50
Catalog Number Size Price Quantity
A16-0012 -- $--

Product Introduction

Lucigenin is a fluoerscent probe that exhibits a bluish-green fluorescence in the presence of superoxide and chloride. It can be used to detect superoxide production by enzymatic and cellular sources.

Chemical Information

Related CAS 22103-92-0 (free base)
Synonyms 10,10'-dimethyl-9,9'-biacridinium, dinitrate; N,N'-Dimethyl-9,9'-biacridinium dinitrate; Lucigenin Nitrate; NSC 151912; Bis(N-methylacridinium) Nitrate; 9,9'-Bis(N-methylacridinium nitrate)
Purity ≥95%
IUPAC Name 10-methyl-9-(10-methylacridin-10-ium-9-yl)acridin-10-ium;dinitrate
Canonical SMILES C[N+]1=C2C=CC=CC2=C(C3=CC=CC=C31)C4=C5C=CC=CC5=[N+](C6=CC=CC=C64)C.[N+](=O)([O-])[O-].[N+](=O)([O-])[O-]
InChI InChI=1S/C28H22N2.2NO3/c1-29-23-15-7-3-11-19(23)27(20-12-4-8-16-24(20)29)28-21-13-5-9-17-25(21)30(2)26-18-10-6-14-22(26)28;2*2-1(3)4/h3-18H,1-2H3;;/q+2;2*-1
InChI Key KNJDBYZZKAZQNG-UHFFFAOYSA-N
Solubility Soluble in Acetic Acid
Appearance Reddish-brown Powder
Melting Point 250°C
  • Product Specification
  • Application
Excitation 455 nm
Emission 505 nm
Storage -20°C
Signal Danger
GHS Hazard Statements H272 (100%): May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids] H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
Precautionary Statement Codes P210, P220, P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, P362+P364, P370+P378, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.)

Lucigenin, a versatile chemical compound central to bioluminescence-based applications, finds diverse utility across various fields. Here are four key applications of Lucigenin:

Reactive Oxygen Species (ROS) Detection: Lucigenin emerges as a beacon in the realm of chemistry, serving as a luminous probe to unveil reactive oxygen species like superoxide anions in biological specimens. Researchers employ Lucigenin to scrutinize oxidative stress levels in cells and tissues, illuminating pathways linked to inflammation, aging, and a spectrum of oxidative stress-related maladies.

Cardiovascular Research: Within the corridors of cardiovascular research, Lucigenin stands tall as an instrument for probing endothelial dynamics and vascular vigor. It finds resonance in assays gauging superoxide production in blood vessels, shedding light on the molecular orchestrations underpinning hypertension, atherosclerosis, and other cardiovascular afflictions.

Environmental Monitoring: Lucigenin, with its luminescent prowess, plays a pivotal role in surveilling our ecosystems. From water to soil, Lucigenin-based assays detect and quantify pollutants and toxins, unveiling the oxidative reverberations provoked by environmental contaminants. This sensitivity, etched in its luminous glow, aids in gauging environmental well-being and identifying potential hazards lurking in the shadows.

Computed Properties

Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 6
Rotatable Bond Count 1
Exact Mass 510.15393443 g/mol
Monoisotopic Mass 510.15393443 g/mol
Topological Polar Surface Area 134Ų
Heavy Atom Count 38
Formal Charge 0
Complexity 522
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 3
Compound Is Canonicalized Yes

Patents

Publication NumberTitlePriority Date
CN-115128062-A Method and use for detecting freshness of food 2022-08-29
CN-115128062-B Method and application of detecting grain freshness 2022-08-29
CN-115112907-A A kind of vitamin B12 quantitative detection kit and its application 2022-07-28
CN-115166264-A A kind of hepcidin detection kit and preparation method thereof 2022-06-30
CN-114994338-A A kind of follicle-stimulating hormone detection kit and preparation method and application thereof 2022-05-26
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