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DBCO-PEG6-NH-Boc
| Catalog Number | R01-0354 |
| Category | Cycloalkyne Dyes (DBCO) |
| Molecular Formula | C38H53N3O10 |
| Molecular Weight | 711.9 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
DBCO-PEG6-NH-Boc is a click chemistry reagent with a DBCO group and a Boc-protected amine. The DBCO can undergo copper-free Click Chemistry reactions with azides. The Boc protecting group can be removed under acidic conditions. The hydrophilic PEG linker increases the water solubility of the compound.
Chemical Information
Product Specification
Application
Computed Properties
| Purity | 98% |
| IUPAC Name | tert-butyl N-[2-[2-[2-[2-[2-[2-[2-[[4-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-4-oxobutanoyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]carbamate |
| Canonical SMILES | CC(C)(C)OC(=O)NCCOCCOCCOCCOCCOCCOCCNC(=O)CCC(=O)N1CC2=CC=CC=C2C#CC3=CC=CC=C31 |
| InChI | InChI=1S/C38H53N3O10/c1-38(2,3)51-37(44)40-17-19-46-21-23-48-25-27-50-29-28-49-26-24-47-22-20-45-18-16-39-35(42)14-15-36(43)41-30-33-10-5-4-8-31(33)12-13-32-9-6-7-11-34(32)41/h4-11H,14-30H2,1-3H3,(H,39,42)(H,40,44) |
| InChIKey | WMGCEDAXFFPJCV-UHFFFAOYSA-N |
| Solubility | DMSO, DCM, DMF |
| Storage | -20 °C |
DBCO-PEG6-NH-Boc, a versatile chemical compound utilized in bioconjugation and click chemistry, serves as a cornerstone in various applications. Here are four key uses:
Bioconjugation: Employing DBCO-PEG6-NH-Boc in bioconjugation methodologies allows for the linking of biomolecules like proteins, peptides, and antibodies, enabling the exploration of their intricate interactions and functionalities. The DBCO group’s precise reaction with azide groups in a bioorthogonal click reaction results in highly selective and efficient conjugation, enhancing the versatility of biomolecules in diagnostic, therapeutic, and research realms.
Drug Delivery: Within drug delivery systems, DBCO-PEG6-NH-Boc plays a pivotal role in modifying therapeutic agents to enhance their solubility, stability, and targeting abilities. The PEGylation imparted by this compound aids in reducing immunogenicity and extending the circulation time of drugs, particularly valuable in crafting targeted therapies with minimized side effects.
Surface Modification: Utilizing DBCO-PEG6-NH-Boc for surface functionalization of nanoparticles, medical devices, and biosensors elevates their biocompatibility and functionality. The PEGylated surface diminishes nonspecific binding while amplifying specific interactions with targeted biomolecules, elevating performance in biomedical applications significantly. This application stands as a linchpin in developing more efficient and reliable diagnostic tools.
Proteomics and Biomarker Discovery: Leveraging the selective reactivity of DBCO-PEG6-NH-Boc with azide-containing probes facilitates the labeling and isolation of specific proteins or peptides. This process streamlines the identification and quantification of biomarkers crucial for disease diagnosis and monitoring, ultimately propelling advancements in personalized medicine and tailored treatment strategies.
| XLogP3 | 1.9 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 10 |
| Rotatable Bond Count | 26 |
| Exact Mass | 711.37309490 g/mol |
| Monoisotopic Mass | 711.37309490 g/mol |
| Topological Polar Surface Area | 143Ų |
| Heavy Atom Count | 51 |
| Formal Charge | 0 |
| Complexity | 1070 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
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