DBCO-mPEG, MW 30,000

DBCO-mPEG MW 30000 is a specialized reagent used primarily in bioconjugation and polymer science. Here are some key applications of DBCO-mPEG MW 30000:

Bioconjugation: DBCO-mPEG facilitates the covalent attachment of polyethylene glycol (PEG) to biomolecules through copper-free click chemistry. This modification improves the solubility, stability, and circulation time of proteins, antibodies, and other therapeutic agents. Consequently, it enhances the efficacy and delivery of biopharmaceuticals.

Drug Delivery: The conjugation of DBCO-mPEG to drug molecules allows for the development of stealth drug delivery systems. PEGylation with DBCO-mPEG reduces the immunogenicity and recognition by the reticuloendothelial system, allowing for prolonged drug circulation in the body. This results in improved therapeutic outcomes and reduced side effects.

Surface Modification: DBCO-mPEG is used to modify the surfaces of nanoparticles, medical devices, and biosensors to create biocompatible and non-fouling surfaces. The PEGylation process prevents protein adsorption and reduces nonspecific interactions, increasing the performance and reliability of these devices. It is particularly useful in developing advanced diagnostic tools and targeted drug delivery systems.

Protein Purification: In protein research, DBCO-mPEG can be employed for the selective purification of protein conjugates. By attaching PEG to target proteins, researchers can leverage size-exclusion chromatography or other PEG-specific purification techniques. This approach simplifies the isolation process and yields high-purity protein samples for further study.