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Bromo-PEG2-azide | 530151-56-5
| Catelog Number | R14-0184 |
| Category | Azides |
| Molecular Formula | C6H12BrN3O2 |
| Molecular Weight | 238.08 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| R14-0184 | -- | $-- |
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Product Introduction
Bromo-PEG2-C2-azide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Chemical Information |
|
|---|---|
| Synonyms | 1-(2-azidoethoxy)-2-(2-bromoethoxy)ethane; Br-PEG2-N3; N3-PEG2-CH2CH2Br; Bromo-PEG2-C2-azide; Ethane, 1-(2-azidoethoxy)-2-(2-bromoethoxy)-; Azido-PEG2-Br |
| Purity | ≥95% |
| IUPAC Name | 1-azido-2-[2-(2-bromoethoxy)ethoxy]ethane |
| Canonical SMILES | C(COCCOCCBr)N=[N+]=[N-] |
| InChI | InChI=1S/C6H12BrN3O2/c7-1-3-11-5-6-12-4-2-9-10-8/h1-6H2 |
| InChI Key | QZCKRLVDTQCBFT-UHFFFAOYSA-N |
| Solubility | Soluble in DCM, DMF, DMSO |
| Appearance | Pale Yellow or Colorless Oily Matter |
| LogP | 0.82 |
Product Specification |
|
|---|---|
| Storage | Store at 2-8°C |
Computed Properties | |
|---|---|
| XLogP3 | 1.6 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 8 |
| Exact Mass | 237.01129 g/mol |
| Monoisotopic Mass | 237.01129 g/mol |
| Topological Polar Surface Area | 32.8Ų |
| Heavy Atom Count | 12 |
| Formal Charge | 0 |
| Complexity | 139 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| KR-20220142393-A | Protein degrader conjugate and the use thereof | 2021-04-14 |
| WO-2022220625-A1 | Protein degrader conjugates and use thereof | 2021-04-14 |
| WO-2021111185-A1 | Compositions and methods related to molecular conjugation | 2019-12-02 |
| WO-2020146521-A2 | Rnai agents for inhibiting expression of hif-2 alpha (epas1), compositions thereof, and methods of use | 2019-01-09 |
| TW-202043470-A | Rnai agents for inhibiting expression of hif-2 alpha (epas1), compositions thereof, and methods of use | 2019-01-09 |
Applications of Fluorescent Probes & Dyes
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