Azido-PEG8-PFP ester

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Azido-PEG8-PFP ester

Azido-PEG8-PFP ester | 2055014-62-3

Catalog Number R14-0294
Category Azides
Molecular Formula C₂₅H₃₆F₅N₃O₁₀
Molecular Weight 633.56
Catalog Number Size Price Quantity
R14-0294 -- $--

Product Introduction

Azido-PEG8-PFP ester is a polyethylene glycol (PEG)-based PROTAC linker. Azido-PEG8-PFP ester can be used in the synthesis of a series of PROTACs.

Chemical Information

Synonyms perfluorophenyl 1-azido-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oate; (2,3,4,5,6-pentafluorophenyl) 3-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate; 2,3,4,5,6-PENTAFLUOROPHENYL 1-AZIDO-3,6,9,12,15,18,21,24-OCTAOXAHEPTACOSAN-27-OATE; 4,7,10,13,16,19,22,25-Octaoxaheptacosanoic acid, 27-azido-, 2,3,4,5,6-pentafluorophenyl ester
Purity 98%
IUPAC Name (2,3,4,5,6-pentafluorophenyl) 3-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
Canonical SMILES C(COCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])C(=O)OC1=C(C(=C(C(=C1F)F)F)F)F
InChI InChI=1S/C25H36F5N3O10/c26-20-21(27)23(29)25(24(30)22(20)28)43-19(34)1-3-35-5-7-37-9-11-39-13-15-41-17-18-42-16-14-40-12-10-38-8-6-36-4-2-32-33-31/h1-18H2
InChI Key FLLXHBTXSPGUHL-UHFFFAOYSA-N
Solubility In DMSO: 100 mg/mL (157.84 mM; Need ultrasonic)
  • Product Specification
Storage -20°C, sealed storage, away from moisture and light; In solvent, -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Computed Properties

XLogP3 1.8
Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 17
Rotatable Bond Count 29
Exact Mass 633.23208516 g/mol
Monoisotopic Mass 633.23208516 g/mol
Topological Polar Surface Area 115Ų
Heavy Atom Count 43
Formal Charge 0
Complexity 732
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

Patents

Publication NumberTitlePriority Date
WO-2020081744-A1 Immunomodulating polynucleotide conjugates and methods of use 2018-10-17
AU-2019360216-A1 Immunomodulating polynucleotide conjugates and methods of use 2018-10-17
BR-112021007294-A2 immunomodulation of polynucleotide conjugates and methods of use 2018-10-17
CA-3116880-A1 Immunomodulating polynucleotide conjugates and methods of use 2018-10-17
EP-3866858-A1 Immunomodulating polynucleotide conjugates and methods of use 2018-10-17
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