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Azido-PEG6-amine | 957486-82-7
| Catalog Number | R14-0265 |
| Category | Azides |
| Molecular Formula | C14H30N4O6 |
| Molecular Weight | 350.41 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| R14-0265 | -- | $-- |
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Product Introduction
Azido-PEG6-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG6-amine is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Chemical Information |
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|---|---|
| Synonyms | O-(2-Aminoethyl)-O'-(2-azidoethyl)pentaethylene Glycol; N3-PEG6-CH2CH2NH2; 20-azido-3,6,9,12,15,18-hexaoxaicosan-1-amine; N3-PEG6-NH2 |
| Purity | ≥95% |
| IUPAC Name | 2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine |
| Canonical SMILES | C(COCCOCCOCCOCCOCCOCCN=[N+]=[N-])N |
| InChI | InChI=1S/C14H30N4O6/c15-1-3-19-5-7-21-9-11-23-13-14-24-12-10-22-8-6-20-4-2-17-18-16/h1-15H2 |
| InChI Key | VCQSTKKJKNUQBI-UHFFFAOYSA-N |
| Solubility | Soluble in DCM, DMF, DMSO, Water |
| Appearance | Pale Yellow or Colorless Oily Matter |
| LogP | 0.50806 |
- Product Specification
| Storage | Store at -20°C, keep in dry and avoid sunlight |
| Signal | Warning |
| GHS Hazard Statements | H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] |
| Precautionary Statement Codes | P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 |
Computed Properties | |
|---|---|
| XLogP3 | -0.7 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 9 |
| Rotatable Bond Count | 20 |
| Exact Mass | 350.21653469 g/mol |
| Monoisotopic Mass | 350.21653469 g/mol |
| Topological Polar Surface Area | 95.8Ų |
| Heavy Atom Count | 24 |
| Formal Charge | 0 |
| Complexity | 292 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| WO-2022219409-A2 | Compositions containing nucleic acid nanoparticles and processes related to alteration of their physicochemical characteristics | 2021-04-15 |
| WO-2022162549-A2 | Immunoconjugates comprising kallikrein related peptidase 2 antigen binding domains and their uses | 2021-01-27 |
| US-2022143231-A1 | Macrocyclic compounds and methods of use thereof | 2020-11-10 |
| WO-2022101771-A1 | Macrocyclic compounds and methods of use thereof | 2020-11-10 |
| US-2022072141-A1 | Protein-drug conjugates comprising camptothecin analogs and methods of use thereof | 2020-07-13 |
Applications of Fluorescent Probes & Dyes
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