Azido-PEG3-t-butyl ester | 252881-73-5

Catelog Number	R14-0243
Category	Azides
Molecular Formula	C13H25N3O5
Molecular Weight	303.35

Catalog Number	Size	Price	Quantity
R14-0243	--	$--

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Product Introduction

N3-PEG3-CH2CH2-Boc is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N3-PEG3-CH2CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

Chemical Information
Synonyms	N3-PEG3-CH2CH2COOtBu;N3-PEG3-tBu; N3-PEG3-CH2CH2-Boc; 3-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]propanoic acid 1,1-dimethylethyl ester; tert-Butyl 12-azido-4,7,10-trioxadocecanoate; 12-Azido-4,7,10-trioxadodecanoic acid tert-butyl ester; 2-Methyl-2-propanyl 3-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}propanoate; Propanoic acid, 3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester
Purity	≥95%
Shelf Life	0-4℃ for short term (days to weeks), or -20℃ for long term (months).
IUPAC Name	tert-butyl 3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]propanoate
Canonical SMILES	CC(C)(C)OC(=O)CCOCCOCCOCCN=[N+]=[N-]
InChI	InChI=1S/C13H25N3O5/c1-13(2,3)21-12(17)4-6-18-8-10-20-11-9-19-7-5-15-16-14/h4-11H2,1-3H3
InChI Key	QUSLQIYNPWASRR-UHFFFAOYSA-N
Solubility	Soluble in DMSO (10 mm)
Appearance	Pale Yellow or Colorless Oily Matter
LogP	1.53106

Product Specification
Storage	Store at -20°C, keep in dry and avoid sunlight
Application	Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. Monodisperse Azido-PEG3-t-butyl ester (N3-PEG3-CH2CH2COOtBu) is a click chemistry reagent containing an azide (N3) and a t-butyl ester moiety. The hydrophilic PEG spacer increases solubility in aqueous media. The azide (N3) group canis reactive with alkyne, such as BCN, DBCO via Click Chemistry. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Product Specification

Storage

Store at -20°C, keep in dry and avoid sunlight

Application

Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.
Monodisperse Azido-PEG3-t-butyl ester (N3-PEG3-CH2CH2COOtBu) is a click chemistry reagent containing an azide (N3) and a t-butyl ester moiety. The hydrophilic PEG spacer increases solubility in aqueous media. The azide (N3) group canis reactive with alkyne, such as BCN, DBCO via Click Chemistry. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Computed Properties
XLogP3	1.5
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	14
Exact Mass	303.17942091 g/mol
Monoisotopic Mass	303.17942091 g/mol
Topological Polar Surface Area	68.4Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	324
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Patents

Publication Number	Title	Priority Date
WO-2022078524-A2	Specific conjugation of an antibody	2021-11-03
WO-2022078524-A4	Specific conjugation of an antibody	2021-11-03
JP-2021006531-A	Cross-linked conjugate for conjugation of cell-binding molecules	2020-09-01
JP-7149610-B2	Specific conjugates of cell binding molecules	2019-11-22
US-2022249594-A1	A formulation of a conjugate of a tubulysin analog to a cell-binding molecule	2019-06-24