Azido-PEG10-Acid

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Azido-PEG10-Acid

Azido-PEG10-Acid | 1644163-57-4

Catalog Number R14-0281
Category Azides
Molecular Formula C23H45N3O12
Molecular Weight 555.62
Catalog Number Size Price Quantity
R14-0281 -- $--

Product Introduction

Azido-PEG10-Acid is a PEG-based PROTAC linker used in the synthesis of PROTACs. It is also a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Chemical Information

Related CAS 1167575-20-3 (polymer)
Synonyms N3-PEG10-COOH; Azido-PEG10-C2-acid; N3-PEG10-CH2CH2COOH; Propanoic acid, 3-[(29-azido-3,6,9,12,15,18,21,24,27-nonaoxanonacos-1-yl)oxy]-; 1-Azido-3,6,9,12,15,18,21,24,27,30-decaoxatritriacontan-33-oic acid; 3,6,9,12,15,18,21,24,27,30-Decaoxatritriacontan-33-oic acid, 1-azido-
Purity ≥95%
IUPAC Name 3-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Canonical SMILES C(COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])C(=O)O
InChI InChI=1S/C23H45N3O12/c24-26-25-2-4-30-6-8-32-10-12-34-14-16-36-18-20-38-22-21-37-19-17-35-15-13-33-11-9-31-7-5-29-3-1-23(27)28/h1-22H2,(H,27,28)
InChI Key UOKQXCSLUSWFRF-UHFFFAOYSA-N
Solubility Soluble in DMF, DMSO, Water
Appearance Pale Yellow Oily Matter
  • Product Specification
  • Application
Storage Store at 2-8°C

Azido-PEG10-Acid, a versatile compound central to biochemical applications such as bioconjugation and targeted delivery systems, finds diverse utility across various disciplines. Here are four key applications of Azido-PEG10-Acid:

Bioconjugation: At the forefront of bioconjugation processes, Azido-PEG10-Acid plays a pivotal role in mediating the attachment of biomolecules such as proteins or antibodies to diverse substrates. Its azide group facilitates seamless click chemistry interactions with alkyne-functionalized molecules, leading to the formation of robust covalent bonds. This capability enables the construction of intricate biomolecular assemblies critical for cutting-edge research and diagnostic endeavors.

Drug Delivery Systems: Redefining the landscape of drug delivery, Azido-PEG10-Acid emerges as a key component in crafting sophisticated delivery platforms. Its PEG chain endows hydrophilicity and biocompatibility, mitigating immunogenic responses and extending circulation time within the bloodstream. By conjugating therapeutic agents to Azido-PEG10-Acid, researchers can engineer targeted delivery vehicles that enhance the effectiveness and safety of medical interventions.

Surface Functionalization: Unleashing its potential in surface modification, Azido-PEG10-Acid transforms the properties of diverse materials to cater to biological applications. From coating nanoparticles to sensor surfaces, this compound enhances stability and biocompatibility, laying the foundation for advanced biosensor technologies and nanomedicine applications. This strategic functionalization approach is instrumental in propelling innovation in the realm of biotechnological developments.

Proteomics and Genomics: Serving as a crucial tool in the realm of proteomics and genomics research, Azido-PEG10-Acid emerges as a linchpin for labeling and scrutinizing biomolecules. By tagging proteins or nucleic acids, this compound enables their precise detection and quantification in complex biological samples. This pivotal application not only unveils insights into molecular interactions but also aids in identifying biomarkers, essential for advancing our understanding of biological systems.

Computed Properties

XLogP3 -0.8
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 14
Rotatable Bond Count 33
Exact Mass 555.30032388 g/mol
Monoisotopic Mass 555.30032388 g/mol
Topological Polar Surface Area 144Ų
Heavy Atom Count 38
Formal Charge 0
Complexity 542
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

Patents

Publication NumberTitlePriority Date
WO-2022240599-A2 Composite solid state electrolyte and lithium ion battery containing the same 2021-05-03
WO-2020190731-A1 Immunoconjugates targeting her2 2019-03-15
WO-2020190734-A1 Immunoconjugates targeting pd-l1 2019-03-15
WO-2020190760-A1 Immunoconjugates targeting cea 2019-03-15
WO-2020190762-A1 Macromolecule-supported tlr agonists 2019-03-15
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