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Azido-PEG1-CH2COOH | 79598-48-4
| Catalog Number | R14-0276 |
| Category | Azides |
| Molecular Formula | C4H7N3O3 |
| Molecular Weight | 145.12 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| R14-0276 | -- | $-- |
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Product Introduction
Azido-PEG1-CH2CO2H is a PEG derivative containing an azide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.
Chemical Information |
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|---|---|
| Synonyms | Azido-PEG1-CH2CO2H;2-azidoethoxyacetic acid; (2-Azidoethyl)oxyacetic Acid; Acetic acid, (2-azidoethoxy)-; N3-PEG1-CH2CO2H; Azido-PEG1-acetic acid |
| Purity | ≥95% |
| IUPAC Name | 2-(2-azidoethoxy)acetic acid |
| Canonical SMILES | C(COCC(=O)O)N=[N+]=[N-] |
| InChI | InChI=1S/C4H7N3O3/c5-7-6-1-2-10-3-4(8)9/h1-3H2,(H,8,9) |
| InChI Key | USTXYASKHZDVMV-UHFFFAOYSA-N |
| Solubility | Soluble in DCM, Water |
| Appearance | Yellowish Oily Matter |
- Product Specification
- Application
| Storage | Store at 2-8°C |
Azido-PEG1-CH2COOH, a versatile compound extensively employed in bioconjugation and click chemistry scenarios, finds diverse applications. Here are four key applications:
Bioconjugation: Azido-PEG1-CH2COOH plays a pivotal role in forging stable covalent bonds between biomolecules. Leveraging its azide group, researchers can seamlessly unite proteins, peptides, or nucleic acids with other functional groups in a precise and controlled fashion. This method is indispensable for crafting targeted drug delivery systems and diagnostic tools.
Surface Modification: In the realm of material science, Azido-PEG1-CH2COOH shines bright as a star for surface modification endeavors. By grafting this compound onto substrates like nanoparticles, polymers, or glass, biocompatibility and functionality experience a substantial boost. This innovation lends itself well to the creation of biosensors, medical implants, and various biomedical devices.
Click Chemistry: Powering the realm of click chemistry, Azido-PEG1-CH2COOH emerges as a cornerstone reagent in rapid and efficient chemical ligation techniques. When paired with alkyne-functionalized compounds, it engages in a copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction, forging stable triazole linkages. This methodology serves as a cornerstone for synthesizing intricate molecular architectures in pharmaceuticals, biomaterials, and chemical biology, showcasing the transformative power of precise chemical manipulation.
Drug Delivery Systems: At the forefront of advanced drug delivery systems, Azido-PEG1-CH2COOH stands tall as an essential component. Its hydrophilic polyethylene glycol (PEG) spacer aids in enhancing the solubility and stability of drugs, while the azide group enables precise conjugation with therapeutic agents.
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