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Nuclear Yellow | CAS 74681-68-8
| Catalog Number | A19-0005 |
| Category | DNA Stains |
| Molecular Formula | C25H28N7O2SCl3 |
| Molecular Weight | 596.96 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Nuclear Yellow is a bright yellow fluorescent nuclear stain for fixed tissue and cytological preparations. It provides sharp nuclear contrast and minimal background.
Chemical Information
Product Specification
Application
Computed Properties
Patents
| Synonyms | 4-[6-[6-(4-Methyl-1-Piperazinyl)-1H-Benzimidazol-2-Yl]-1H-Benzimidazol-2-Yl]Benzenesulfonamide Trihydrochloride;4-(5-(4-Methyl-1-Piperazinyl)(2,5'-Bi-1H-Benzimidazol)-2'-Yl)Benzenesulfonamide Trihydrochloride;Hoe-S769121;2-(4-Sulfamylphenyl)-6-[6-(4-methylpiperazino)-2-benzimidazolyl]benzimidazole trihydrochloride |
| Purity | 98% |
| Shelf Life | 2 month in rt, long time |
| IUPAC Name | 4-[6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazol-2-yl]benzenesulfonamide;trihydrochloride |
| Canonical SMILES | CN1CCN(CC1)C2=CC3=C(C=C2)N=C(N3)C4=CC5=C(C=C4)N=C(N5)C6=CC=C(C=C6)S(=O)(=O)N.Cl.Cl.Cl |
| InChI | InChI=1S/C25H25N7O2S.3ClH/c1-31-10-12-32(13-11-31)18-5-9-21-23(15-18)30-25(28-21)17-4-8-20-22(14-17)29-24(27-20)16-2-6-19(7-3-16)35(26,33)34;;;/h2-9,14-15H,10-13H2,1H3,(H,27,29)(H,28,30)(H2,26,33,34);3*1H |
| InChIKey | NZVGXJAQIQJIOY-UHFFFAOYSA-N |
| Solubility | H2O: ≥ 6 mg/mL, DMSO: < 12.2 mg/mL |
| Appearance | Light yellow powder |
| Boiling Point | 813.6°C at 760 mmHg |
| Excitation | 355 nm |
| Emission | 495 nm |
| Storage | -20°C Freezer, Protect from light |
Nuclear Yellow is a fluorescent dye used in various bioscience applications for staining and visualization purposes. Here are some key applications of Nuclear Yellow:
Cell Nucleus Staining: Nuclear Yellow is commonly used to stain the nuclei of cells in both live and fixed samples. This helps researchers visualize nuclear structures and identify specific cell populations under a fluorescence microscope. The bright yellow fluorescence emitted by the stained nuclei contrasts well with other fluorescent markers, aiding in detailed cellular studies.
Apoptosis Detection: The dye is also employed in apoptosis assays to identify and quantify apoptotic cells. During apoptosis, nuclear condensation and fragmentation occur, which can be effectively visualized using Nuclear Yellow. This makes it a valuable tool for assessing cell viability and the efficacy of anticancer therapies in research.
Chromosome Analysis: In cytogenetics, Nuclear Yellow is used for chromosome staining during metaphase spreads. This application is particularly useful for karyotyping, where researchers can identify chromosomal abnormalities and study genetic disorders. The distinct fluorescence of Nuclear Yellow aids in the clear visualization of chromosomal structures.
Biomedical Imaging: Nuclear Yellow is utilized in advanced imaging techniques, such as confocal microscopy and flow cytometry. By staining nuclei with Nuclear Yellow, scientists can obtain high-resolution images and accurate data on cellular characteristics. This enhances the study of cell cycle dynamics, gene expression, and cellular differentiation in various research fields.
| Hydrogen Bond Donor Count | 6 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 4 |
| Exact Mass | 595.109077 g/mol |
| Monoisotopic Mass | 595.109077 g/mol |
| Topological Polar Surface Area | 132Ų |
| Heavy Atom Count | 38 |
| Formal Charge | 0 |
| Complexity | 837 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 4 |
| Compound Is Canonicalized | Yes |
| Publication Number | Title | Priority Date |
|---|---|---|
| WO-2020161125-A1 | Methods and systems for evaluation of immune cell infiltrate in stage iv colorectal cancer | 2019-02-05 |
| CN-113454458-A | Methods and systems for assessing immune cell infiltration in stage IV colorectal cancer | 2019-02-05 |
| EP-3921648-A1 | Methods and systems for evaluation of immune cell infiltrate in stage iv colorectal cancer | 2019-02-05 |
| US-2021373024-A1 | Methods and systems for evaluation of immune cell infiltrate in stage iv colorectal cancer | 2019-02-05 |
| WO-2020104538-A1 | Methods and systems for preparing and analyzing cellular samples for morphological characteristics and biomarker expression | 2018-11-20 |
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