Nuclear Yellow | 74681-68-8
Catelog Number | A19-0005 |
Category | DNA Stains |
Molecular Formula | C25H28N7O2SCl3 |
Molecular Weight | 596.96 |
Catalog Number | Size | Price | Quantity |
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A19-0005 | -- | $-- |
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Product Introduction
Nuclear yellow, as Hoechst S769121, belongs Hoechst stains, which were originally developed by Hoechst AG, which numbered all their compounds and are soluble in water and in organic solvents such as dimethyl formamide or dimethyl sulfoxide. It is the long-wavelength tracer and is often combined with the popular retrograde tracer true blue for two-color neuronal mapping. It exhibits excitation/emission maxima ~335/495 nm when bound to DNA. In neuronal cells, it primarily stains the nucleus with yellow fluorescence. It is stable when subjected to immunohistochemical processing and can be used to photoconvert DAB into an insoluble, electron-dense reaction product.
Chemical Information |
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Synonyms | 4-[6-[6-(4-Methyl-1-Piperazinyl)-1H-Benzimidazol-2-Yl]-1H-Benzimidazol-2-Yl]Benzenesulfonamide Trihydrochloride;4-(5-(4-Methyl-1-Piperazinyl)(2,5'-Bi-1H-Benzimidazol)-2'-Yl)Benzenesulfonamide Trihydrochloride;Hoe-S769121;2-(4-Sulfamylphenyl)-6-[6-(4-methylpiperazino)-2-benzimidazolyl]benzimidazole trihydrochloride |
Purity | 98% |
Shelf Life | 2 month in rt, long time |
IUPAC Name | 4-[6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazol-2-yl]benzenesulfonamide;trihydrochloride |
Canonical SMILES | CN1CCN(CC1)C2=CC3=C(C=C2)N=C(N3)C4=CC5=C(C=C4)N=C(N5)C6=CC=C(C=C6)S(=O)(=O)N.Cl.Cl.Cl |
InChI | InChI=1S/C25H25N7O2S.3ClH/c1-31-10-12-32(13-11-31)18-5-9-21-23(15-18)30-25(28-21)17-4-8-20-22(14-17)29-24(27-20)16-2-6-19(7-3-16)35(26,33)34;;;/h2-9,14-15H,10-13H2,1H3,(H,27,29)(H,28,30)(H2,26,33,34);3*1H |
InChI Key | NZVGXJAQIQJIOY-UHFFFAOYSA-N |
Solubility | H2O: ≥ 6 mg/mL, DMSO: < 12.2 mg/mL |
Appearance | Light yellow powder |
Boiling Point | 813.6°C at 760 mmHg |
Product Specification |
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Excitation | 355 nm |
Emission | 495 nm |
Storage | -20°C Freezer, Protect from light |
Application | Nuclear yellow exhibits excitation/emission maxima ~335/495 nm when bound to DNA. In neuronal cells, it primarily stains the nucleus with yellow fluorescence. |
Computed Properties | |
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Hydrogen Bond Donor Count | 6 |
Hydrogen Bond Acceptor Count | 7 |
Rotatable Bond Count | 4 |
Exact Mass | 595.109077 g/mol |
Monoisotopic Mass | 595.109077 g/mol |
Topological Polar Surface Area | 132Ų |
Heavy Atom Count | 38 |
Formal Charge | 0 |
Complexity | 837 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently-Bonded Unit Count | 4 |
Compound Is Canonicalized | Yes |
Patents
Publication Number | Title | Priority Date |
---|---|---|
WO-2020161125-A1 | Methods and systems for evaluation of immune cell infiltrate in stage iv colorectal cancer | 2019-02-05 |
CN-113454458-A | Methods and systems for assessing immune cell infiltration in stage IV colorectal cancer | 2019-02-05 |
EP-3921648-A1 | Methods and systems for evaluation of immune cell infiltrate in stage iv colorectal cancer | 2019-02-05 |
US-2021373024-A1 | Methods and systems for evaluation of immune cell infiltrate in stage iv colorectal cancer | 2019-02-05 |
WO-2020104538-A1 | Methods and systems for preparing and analyzing cellular samples for morphological characteristics and biomarker expression | 2018-11-20 |
Applications of Fluorescent Probes & Dyes
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