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DiBAC4(3) | CAS 70363-83-6
| Catalog Number | A16-0172 |
| Category | Cell membrane Fluorescent Probes |
| Molecular Formula | C27H40N4O6 |
| Molecular Weight | 516.64 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
DiBAC4(3) is a slow-response, anionic, lipophilic green-fluorescent dye used for measurement of plasma membrane voltage potentials in live cells.
Chemical Information
Product Specification
Application
| Synonyms | Bis(1,3-dibutylbarbituric acid) trimethine oxonol |
| Appearance | Solid Powder |
| Excitation | 493 nm |
| Emission | 517 nm |
DiBAC4(3), a fluorescent dye sensitive to membrane potential, is a versatile tool in the realms of cell membrane dynamics and electrophysiological investigations. Here are four key applications of DiBAC4(3):
Cell Viability Assays: Leveraging its unique properties, DiBAC4(3) is a staple in cell viability assessments, shedding light on membrane potential variations linked to cell health and apoptosis. By scrutinizing changes in fluorescence intensity, researchers unravel the well-being of cells.
Neuroscience Research: In the intricate domain of neuroscience, DiBAC4(3) takes center stage to explore the electrophysiological characteristics of neurons and excitable cells. The fluctuations in membrane potential, manifested through DiBAC4(3) fluorescence, offer insights into neuronal communication, synaptic functions, and the repercussions of pharmacological interventions.
Microbial Physiology: Delving into the microbial world, DiBAC4(3) serves as a window into membrane potential dynamics within bacterial cells, unraveling clues about microbial physiology and pathogenicity. Through vigilantly monitoring alterations in fluorescence, scientists dissect the impacts of antimicrobial substances on bacterial membrane potential. This aids in appraising the efficacy of novel antibiotics and deciphering the mechanisms of bacterial resistance.
Drug Mechanism Studies: DiBAC4(3) emerges as a critical tool in deciphering the mechanisms of action of diverse pharmaceutical agents influencing membrane potential. By keenly observing the shifts in DiBAC4(3) fluorescence induced by various compounds, researchers decode the interactions of drugs with ion channels, transporters, and other membrane proteins.
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