DiBAC4(3) | CAS 70363-83-6

Catalog Number	A16-0172
Category	Cell membrane Fluorescent Probes
Molecular Formula	C27H40N4O6
Molecular Weight	516.64

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Product Introduction

DiBAC4(3) is a voltage-sensitive bis-oxonol dye for measuring cell membrane potential. It’s widely used in cell viability and electrophysiology assays.

Chemical Information
Product Specification
Application

Synonyms	Bis(1,3-dibutylbarbituric acid) trimethine oxonol
Appearance	Solid Powder

Excitation	493 nm
Emission	517 nm

DiBAC4(3), a fluorescent dye sensitive to membrane potential, is a versatile tool in the realms of cell membrane dynamics and electrophysiological investigations. Here are four key applications of DiBAC4(3):

Cell Viability Assays: Leveraging its unique properties, DiBAC4(3) is a staple in cell viability assessments, shedding light on membrane potential variations linked to cell health and apoptosis. By scrutinizing changes in fluorescence intensity, researchers unravel the well-being of cells.

Neuroscience Research: In the intricate domain of neuroscience, DiBAC4(3) takes center stage to explore the electrophysiological characteristics of neurons and excitable cells. The fluctuations in membrane potential, manifested through DiBAC4(3) fluorescence, offer insights into neuronal communication, synaptic functions, and the repercussions of pharmacological interventions.

Microbial Physiology: Delving into the microbial world, DiBAC4(3) serves as a window into membrane potential dynamics within bacterial cells, unraveling clues about microbial physiology and pathogenicity. Through vigilantly monitoring alterations in fluorescence, scientists dissect the impacts of antimicrobial substances on bacterial membrane potential. This aids in appraising the efficacy of novel antibiotics and deciphering the mechanisms of bacterial resistance.

Drug Mechanism Studies: DiBAC4(3) emerges as a critical tool in deciphering the mechanisms of action of diverse pharmaceutical agents influencing membrane potential. By keenly observing the shifts in DiBAC4(3) fluorescence induced by various compounds, researchers decode the interactions of drugs with ion channels, transporters, and other membrane proteins.