coumarin-SAHA | 1260635-77-5
Catelog Number | A18-0018 |
Category | Fluorescent Enzyme Substrates |
Molecular Formula | C18H22N2O5 |
Molecular Weight | 346.4 |
Catalog Number | Size | Price | Quantity |
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A18-0018 | -- | $-- |
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Product Introduction
Suberoylanilide hydroxamic acid (SAHA) is a histone deacetylase (HDAC) inhibitor. Coumarin-Suberoylanilide hydroxamic acid (c-SAHA) is a SAHA derivative where the anilino "cap" group is replaced by 7-amino-4-methylcoumarin to produce a fluorescent probe that competitively binds HDAC. coumarin-SAHA is used to determine binding affinities and dissociation off-rates of HDAC enzyme-inhibitor complexes.
Chemical Information |
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Synonyms | Coumarin-Suberoylanilide Hydroxamic Acid; N1-hydroxy-N8-(4-methyl-2-oxo-2H-chromen-7-yl)-octanediamide |
Purity | ≥98% |
Canonical SMILES | CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)CCCCCCC(=O)NO |
InChI | InChI=1S/C18H22N2O5/c1-12-10-18(23)25-15-11-13(8-9-14(12)15)19-16(21)6-4-2-3-5-7-17(22)20-24/h8-11,24H,2-7H2,1H3,(H,19,21)(H,20,22) |
InChI Key | YSRCADVJNRJJAV-UHFFFAOYSA-N |
Appearance | Solid Powder |
Product Specification |
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Excitation | 325 nm |
Emission | 400 nm |
Storage | Store at -20°C |
Applications of Fluorescent Probes & Dyes
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