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Calcein AM | 148504-34-1
| Catelog Number | A18-0014 |
| Category | Fluorescent Enzyme Substrates |
| Molecular Formula | C46H46N2O23 |
| Molecular Weight | 994.9 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| A18-0014 | -- | $-- |
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Product Introduction
Calcein AM is a non-fluorescent, cell-permeable derivative of calcein, a self-quenching fluorescent dye. Calcein AM can be cleaved to release calcein in cells. Calcein is used as a substrate for multidrug resistance-associated protein 1 (MRP1) and multidrug resistance protein 3 (MDR3, P-glycoprotein 3).
Chemical Information |
|
|---|---|
| Synonyms | Calcein Acetoxymethyl ester; N,N'-[[3',6'-bis(acetyloxy)-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-2',7'-diyl]bis(methylene)]bis[N-[2-[(acetyloxy)methoxy]-2-oxoethyl]]-glycine, 1,1'-bis[(acetyloxy)methyl] ester |
| Purity | ≥90% |
| IUPAC Name | acetyloxymethyl 2-[[2-(acetyloxymethoxy)-2-oxoethyl]-[[3',6'-diacetyloxy-7'-[[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]methyl]-3-oxospiro[2-benzofuran-1,9'-xanthene]-2'-yl]methyl]amino]acetate |
| Canonical SMILES | CC(=O)OCOC(=O)CN(CC1=C(C=C2C(=C1)C3(C4=CC=CC=C4C(=O)O3)C5=CC(=C(C=C5O2)OC(=O)C)CN(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C)OC(=O)C)CC(=O)OCOC(=O)C |
| InChI | InChI=1S/C46H46N2O23/c1-25(49)60-21-64-41(55)17-47(18-42(56)65-22-61-26(2)50)15-31-11-35-39(13-37(31)68-29(5)53)70-40-14-38(69-30(6)54)32(12-36(40)46(35)34-10-8-7-9-33(34)45(59)71-46)16-48(19-43(57)66-23-62-27(3)51)20-44(58)67-24-63-28(4)52/h7-14H,15-24H2,1-6H3 |
| InChI Key | BQRGNLJZBFXNCZ-UHFFFAOYSA-N |
| Appearance | Solid Powder |
Product Specification |
|
|---|---|
| Excitation | 494 nm |
| Emission | 517 nm |
| Storage | Store at -20°C |
Computed Properties | |
|---|---|
| XLogP3 | 2.9 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 25 |
| Rotatable Bond Count | 32 |
| Exact Mass | 994.24913572 g/mol |
| Monoisotopic Mass | 994.24913572 g/mol |
| Topological Polar Surface Area | 305Ų |
| Heavy Atom Count | 71 |
| Formal Charge | 0 |
| Complexity | 1810 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 34896433 | 2022-01-01 | Alisertib shows negligible potential for perpetrating pharmacokinetic drug-drug interactions on ABCB1, ABCG2 and cytochromes P450, but acts as dual-activity resistance modulator through the inhibition of ABCC1 transporter | Toxicology and applied pharmacology |
| 30925062 | 2019-05-09 | Identification of Thienopyrimidine Scaffold as an Inhibitor of the ABC Transport Protein ABCC1 (MRP1) and Related Transporters Using a Combined Virtual Screening Approach | Journal of medicinal chemistry |
| 30217652 | 2019-02-01 | Mifepristone potentiates etoposide toxicity in Hep G2 cells by modulating drug transport | Toxicology in vitro : an international journal published in association with BIBRA |
| 30391378 | 2019-01-01 | 5-Oxo-hexahydroquinoline derivatives as modulators of P-gp, MRP1 and BCRP transporters to overcome multidrug resistance in cancer cells | Toxicology and applied pharmacology |
| 29174985 | 2018-03-01 | Role of P-glycoprotein in deoxynivalenol-mediated in vitro toxicity | Toxicology letters |
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-115177788-A | A PCL composite biological collagen membrane with good mechanical strength and cell activity and its application | 2022-09-13 |
| CN-115177788-B | A kind of PCL composite biological collagen membrane with good mechanical strength and cell activity and its application | 2022-09-13 |
| CN-115105624-A | A kind of marine polysaccharide-based high-efficiency antibacterial film dressing and preparation method thereof | 2022-08-26 |
| CN-115105624-B | A marine polysaccharide-based high-efficiency antibacterial film dressing and preparation method thereof | 2022-08-26 |
| JP-2022163215-A | Neurogenesis stimulant, internal medicine, medium additive, cell diluent additive, medium and cell diluent | 2022-08-18 |
Applications of Fluorescent Probes & Dyes
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