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Ac-RLR-AMC trifluoroacetate salt
| Catalog Number | A18-0048 |
| Category | Fluorescent Enzyme Substrates |
| Molecular Formula | C30H46N10O6·CF3COOH |
| Molecular Weight | 756.8 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| A18-0048 | -- | -- |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Ac-RLR-AMC is a fluorogenic substrate for the 26S proteasome. Ac-RLR-AMC is cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the trypsin-like activity of 26S proteasomes.
Chemical Information
Product Specification
Application
| Synonyms | Ac-Arg-Leu-Arg-7-amino-4-methylcoumarin; (S)-2-acetamido-5-guanidino-N-((S)-1-(((S)-5-guanidino-1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)pentanamide, 2,2,2-trifluoroacetate salt |
| Purity | ≥98% |
| Excitation | 380 nm |
| Emission | 440-460 nm |
| Storage | Store at -20°C |
Ac-RLR-AMC trifluoroacetate salt, a synthetic substrate renowned for its role in unveiling enzyme activity and kinetics, finds widespread application in biochemical research and drug development. Here are four key applications of Ac-RLR-AMC trifluoroacetate salt:
Protease Activity Assays: At the forefront of scientific inquiry, Ac-RLR-AMC trifluoroacetate salt is a cornerstone in fluorescence-based assays, offering insights into the activity of proteolytic enzymes. Upon cleavage by a protease, the substrate liberates a fluorescent AMC (7-amino-4-methylcoumarin) molecule, facilitating quantification via a fluorometer. This methodology empowers researchers to evaluate protease activity, screen for inhibitors, and explore enzyme kinetics across diverse biological samples.
Drug Discovery: In the realm of drug development, Ac-RLR-AMC trifluoroacetate salt emerges as a pivotal instrument for high-throughput screening assays, expediting the assessment of compound libraries for potential protease inhibitors. By delivering a discernible and quantifiable output, this substrate accelerates the identification of lead compounds that hold promise for further development into therapeutic agents targeting diseases linked to protease activity, notably cancer and infectious diseases.
Biochemical Pathway Studies: Delving into the intricacies of biochemical pathways involving proteases, researchers turn to Ac-RLR-AMC trifluoroacetate salt as a linchpin for their investigations. By dissecting how various proteases interact with this substrate, scientists unravel the specific roles these enzymes play in cellular processes. This knowledge enriches our comprehension of complex signaling pathways and drives the advancement of tailored treatments for associated disorders.
Clinical Diagnostics: In the domain of clinical diagnostics, Ac-RLR-AMC trifluoroacetate salt emerges as a pivotal tool for evaluating protease levels in patient samples, aiding in disease diagnosis and monitoring. Elevated protease activity, detected using this substrate, can serve as a biomarker for certain cancers or inflammatory conditions. Its application ensures sensitive and precise detection of protease activities, contributing to the realm of personalized medicine and strategies for disease management.
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