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7-Ethoxy-4-trifluoromethylcoumarin | 115453-82-2
| Catelog Number | A18-0068 |
| Category | Fluorescent Enzyme Substrates |
| Molecular Formula | C12H9F3O3 |
| Molecular Weight | 258.19 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| A18-0068 | -- | $-- |
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Product Introduction
7-Ethoxy-4-trifluoromethylcoumarin is a fluorogenic substrate for cytochrome P-450 to determine the enzymatic activity.
Chemical Information |
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|---|---|
| Synonyms | 7-Ethoxy-4-(trifluoromethyl)coumarin; 7-ethoxy-4-(trifluoromethyl)-2H-chromen-2-one; 7-ethoxy-4-(trifluoromethyl)chromen-2-one |
| IUPAC Name | 7-ethoxy-4-(trifluoromethyl)chromen-2-one |
| Canonical SMILES | CCOC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F |
| InChI | InChI=1S/C12H9F3O3/c1-2-17-7-3-4-8-9(12(13,14)15)6-11(16)18-10(8)5-7/h3-6H,2H2,1H3 |
| InChI Key | OLHOIERZAZMHGK-UHFFFAOYSA-N |
Computed Properties | |
|---|---|
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 2 |
| Exact Mass | 258.05037863 g/mol |
| Monoisotopic Mass | 258.05037863 g/mol |
| Topological Polar Surface Area | 35.5Ų |
| Heavy Atom Count | 18 |
| Formal Charge | 0 |
| Complexity | 362 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 23850985 | 2013-09-01 | Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system | Toxicology in vitro : an international journal published in association with BIBRA |
| 22888116 | 2012-11-01 | Increase of human CYP1B1 activities by acidic phospholipids and kinetic deuterium isotope effects on CYP1B1 substrate oxidation | Journal of biochemistry |
| 21964418 | 2011-11-15 | Characterization of inhibitory effects of perfluorooctane sulfonate on human hepatic cytochrome P450 isoenzymes: focusing on CYP2A6 | Chemico-biological interactions |
| 21659470 | 2011-09-01 | Polymorphic variants of cytochrome P450 2B6 (CYP2B6.4-CYP2B6.9) exhibit altered rates of metabolism for bupropion and efavirenz: a charge-reversal mutation in the K139E variant (CYP2B6.8) impairs formation of a functional cytochrome p450-reductase complex | The Journal of pharmacology and experimental therapeutics |
| 21510666 | 2011-06-07 | Structural analysis of mammalian cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene: insight into partial enzymatic activity | Biochemistry |
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| WO-2021074162-A1 | Genetically modified human stem cell expressing a mutant human cytochrome p450 2b6 protein and use thereof in the treatment of cancer | 2019-10-14 |
| WO-2021074167-A1 | Genetically modified human stem cell expressing a mutant human cytochrome p450 2b6 protein and use thereof in the treatment of cancer | 2019-10-14 |
| TW-202128986-A | Cellule souche humaine génétiquement modifiée exprimant une protéine cytochrome p450 2b6 humaine mutante et son utilisation dans le traitement du cancer | 2019-10-14 |
| EP-4045633-A1 | Genetically modified human stem cell expressing a mutant human cytochrome p450 2b6 protein and use thereof in the treatment of cancer | 2019-10-14 |
| EP-4045634-A1 | Genetically modified human stem cell expressing a mutant human cytochrome p450 2b6 protein and use thereof in the treatment of cancer | 2019-10-14 |
Applications of Fluorescent Probes & Dyes
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