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Di-4-ANEPPS | CAS 90134-00-2
| Catalog Number | A16-0060 |
| Category | Mitochondrial Fluorescent Probes |
| Molecular Formula | C28H36N2O3S |
| Molecular Weight | 480.7 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Di-4-ANEPPS is a fluorescent dye for monitoring membrane potential. The fluorescence changes proportionally to cell membrane potential.
Chemical Information
Product Specification
Application
Computed Properties
Patents
| Synonyms | 4-[2-[6-(dibutylamino)-2-naphthalenyl]ethenyl]-1-(3-sulfopropyl)-pyridinium inner salt; 3-(4-(2-(6-(Dibutylamino)naphthalen-2-yl)vinyl)pyridinium-1-yl)propane-1-sulfonate |
| Purity | ≥98% |
| IUPAC Name | 3-[4-[(E)-2-[6-(dibutylamino)naphthalen-2-yl]ethenyl]pyridin-1-ium-1-yl]propane-1-sulfonate |
| Canonical SMILES | CCCCN(CCCC)C1=CC2=C(C=C1)C=C(C=C2)C=CC3=CC=[N+](C=C3)CCCS(=O)(=O)[O-] |
| InChI | InChI=1S/C28H36N2O3S/c1-3-5-17-30(18-6-4-2)28-13-12-26-22-25(10-11-27(26)23-28)9-8-24-14-19-29(20-15-24)16-7-21-34(31,32)33/h8-15,19-20,22-23H,3-7,16-18,21H2,1-2H3 |
| InChIKey | HAPJROQJVSPKCJ-UHFFFAOYSA-N |
| Appearance | Solid Powder |
| Storage | Store at -20°C |
Di-4-ANEPPS, a voltage-sensitive dye utilized in biological and physiological research to monitor membrane potential fluctuations, finds diverse applications across various fields. Here are four key applications of Di-4-ANEPPS:
Cardiac Electrophysiology: Widely employed in the study of cardiac action potentials in both isolated heart tissues and cultured cardiomyocytes, Di-4-ANEPPS enables high-resolution real-time visualization of electrical activity throughout cardiac cells. This crucial application plays a pivotal role in unraveling the complexities of cardiac arrhythmias and in the development of innovative therapeutic strategies.
Neuroscience: In the realm of neuroscience research, Di-4-ANEPPS serves as a valuable tool for monitoring neuronal activity and synaptic transmissions. By tracking changes in membrane potential, researchers can intricately map neuronal networks and delve into the intricate workings of brain function. This technology is instrumental in dissecting the mechanisms underlying debilitating neurological disorders like epilepsy and Alzheimer’s disease.
Cellular Bioenergetics: Delving into mitochondrial membrane potential alterations within cells, Di-4-ANEPPS offers insights into cellular energy dynamics and metabolic processes. This application holds significance in the study of various diseases, including metabolic disorders and cancer, shedding light on how cells regulate energy production and how these regulatory mechanisms become disrupted in disease states.
High-Throughput Screening: Employed in drug screening assays to assess the impact of compounds on membrane potential, Di-4-ANEPPS plays a crucial role in identifying potential therapeutic agents that modulate ion channels and other membrane-associated proteins. The utilization of Di-4-ANEPPS in high-throughput screening enhances the discovery of novel drugs targeting cardiac, neuronal, and metabolic conditions, paving the way for advancements in drug development and precision medicine.
| XLogP3 | 6.2 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 12 |
| Exact Mass | 480.24466419 g/mol |
| Monoisotopic Mass | 480.24466419 g/mol |
| Topological Polar Surface Area | 72.7Ų |
| Heavy Atom Count | 34 |
| Formal Charge | 0 |
| Complexity | 676 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 1 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
| Publication Number | Title | Priority Date |
|---|---|---|
| WO-2017073728-A1 | Ultrathin film photoluminescence sensor | 2015-10-30 |
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