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DISBAC10 | CAS 169211-45-4
| Catalog Number | A16-0031 |
| Category | Cell membrane Fluorescent Probes |
| Molecular Formula | C51H88N4O4S2 |
| Molecular Weight | 885.4 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
DISBAC10 is a voltage-sensitive fluorescent probe used to study cell membrane electrical activity in FRET assays. In a resting polarized cell, DISBAC10 resides on the outer leaflet of the membrane where it accepts photons from excited fluorescein-labeled proteins and re-emits the photons at a higher wavelength. Depolarization of the cell causes rapid translocation of DISBAC10 to the inner leaflet of the membrane, thereby increasing the distance between fluorophores and reducing the FRET signal.
Chemical Information
Product Specification
Application
Computed Properties
| Synonyms | 1,3-didecyl-5-[3-(1,3-didecylhexahydro-4,6-dioxo-2-thioxo-5-pyrimidinyl)-2-propenylidene]dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione |
| Purity | ≥98% |
| IUPAC Name | 1,3-didecyl-5-[3-(1,3-didecyl-4,6-dioxo-2-sulfanylidene-1,3-diazinan-5-yl)prop-2-enylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione |
| Canonical SMILES | CCCCCCCCCCN1C(=O)C(C(=O)N(C1=S)CCCCCCCCCC)C=CC=C2C(=O)N(C(=S)N(C2=O)CCCCCCCCCC)CCCCCCCCCC |
| InChI | InChI=1S/C51H90N4O4S2/c1-5-9-13-17-21-25-29-33-40-52-46(56)44(47(57)53(50(52)60)41-34-30-26-22-18-14-10-6-2)38-37-39-45-48(58)54(42-35-31-27-23-19-15-11-7-3)51(61)55(49(45)59)43-36-32-28-24-20-16-12-8-4/h37-39,44,46,56H,5-36,40-43H2,1-4H3/b38-37+ |
| InChIKey | XDRMUCPEPWWVLX-HEFFKOSUSA-N |
| Excitation | 540 nm |
| Emission | 560 nm |
| Storage | Store at -20°C |
DISBAC10 is a fluorescent probe widely recognized for its ability to permeate cell membranes, making it an invaluable tool in cellular biology and biochemistry. Its unique properties allow researchers to visualize and analyze various cellular processes. Below are four key applications of DISBAC10.
Cell Membrane Integrity Assessment: DISBAC10 is primarily used for evaluating cell membrane integrity. When cells are compromised, DISBAC10 can penetrate the membrane and bind to intracellular components, emitting fluorescence. This property makes it an excellent indicator of cell viability and membrane stability. Researchers often employ DISBAC10 to assess the effects of toxic substances, drugs, or environmental factors on cell membranes, providing crucial insights into cellular health and the underlying mechanisms of cytotoxicity.
Studying Apoptosis and Cell Death Mechanisms: In the realm of apoptosis research, DISBAC10 serves as a critical tool for identifying and studying cell death mechanisms. As cells undergo apoptosis, changes in membrane permeability occur, allowing DISBAC10 to enter. By monitoring the fluorescence intensity of DISBAC10, scientists can track the progression of apoptosis in real-time. This application is particularly valuable in cancer research, where understanding the mechanisms of tumor cell death can lead to the development of more effective therapeutic strategies.
Monitoring Drug Delivery and Release: DISBAC10 is also utilized in the field of drug delivery systems. Its ability to easily cross cell membranes allows researchers to evaluate the efficiency of drug encapsulation and release from nanoparticles or other delivery vehicles. By tagging therapeutic agents with DISBAC10, scientists can visualize the distribution and release kinetics within target cells. This capability is essential for optimizing drug formulations and enhancing the efficacy of targeted therapies, especially in cancer and chronic diseases.
Investigating Membrane Dynamics and Cellular Processes: Another critical application of DISBAC10 is in the investigation of membrane dynamics and various cellular processes. Researchers utilize DISBAC10 to study phenomena such as endocytosis, exocytosis, and membrane fusion. By tracking the fluorescent signal in live cells, scientists can gain insights into the mechanisms underlying these dynamic processes, contributing to our understanding of cellular communication and transport. This application is crucial for advancing knowledge in cell biology and developing new therapeutic approaches targeting membrane-associated pathways.
| XLogP3 | 18.5 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 38 |
| Exact Mass | 884.62469965 g/mol |
| Monoisotopic Mass | 884.62469965 g/mol |
| Topological Polar Surface Area | 145Ų |
| Heavy Atom Count | 61 |
| Formal Charge | 0 |
| Complexity | 1260 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 1 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
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