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Vancomycin, BODIPY FL Conjugate

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Vancomycin, BODIPY FL Conjugate

Catalog Number	F01-0212
Category	BODIPY
Molecular Formula	C80H88BCl2F2N11O25
Molecular Weight	1723.33

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Product Introduction

Vancomycin, BODIPY FL Conjugate is a green-fluorescent derivative of the antibiotic vancomycin, which binds to the terminal D-alanyl-D-alanine moieties of peptidoglycan peptides in cell walls of gram-positive bacteria. It has been used for investigations of vancomycin binding and transport on cell membranes of bacteria. This compound is relatively insensitive to environment and pH changes.

Chemical Information
Product Specification
Application

Synonyms	Vancomycin, EverFluor FL Conjugate
Appearance	Solid Powder

Excitation	572
Emission	598

Vancomycin BODIPY FL Conjugate, a fusion of antibiotic and fluorescent dye, serves various purposes in medical and research domains. Here are four significant applications of Vancomycin BODIPY FL Conjugate:

Bacterial Imaging: Deployed in imaging investigations, the Vancomycin BODIPY FL Conjugate aids in visually tracking bacterial infections. By selectively binding to bacterial cell walls, the conjugate’s fluorescent attributes enable researchers to visually map and pinpoint bacterial colonies within samples. This utilization facilitates comprehension of infection kinetics and assessment of antibacterial treatment efficacy.

Antibiotic Mechanism Studies: This conjugate plays a pivotal role in dissecting the mechanism of action of vancomycin. It empowers researchers to monitor the interactions between vancomycin and bacterial cells, as well as its impact on bacterial proliferation and viability. Such insights are indispensable for enhancing antibiotic efficiency and combating drug-resistant bacterial variants.

Pharmacokinetics: In the realm of pharmaceutical exploration, Vancomycin BODIPY FL Conjugate is harnessed to monitor the distribution and localization of vancomycin within biological systems. Its fluorescence enables real-time, non-invasive monitoring of the drug’s trajectory in vivo, furnishing crucial insights into its absorption, distribution, metabolism, and excretion dynamics. This data is paramount for optimizing dosing schedules and enhancing therapeutic effectiveness.

Biofilm Studies: The conjugate emerges as a valuable tool in investigating bacterial biofilms, intricate bacterial communities with heightened resistance to antibiotics. By leveraging the conjugate to target biofilms, researchers can evaluate vancomycin’s penetration and efficacy in disrupting biofilm architectures.