TFA-Hexylaminolinker Phosphoramidite

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TFA-Hexylaminolinker Phosphoramidite

TFA-Hexylaminolinker Phosphoramidite | 133975-85-6

Catelog Number R10-0011
Category DNA Stains
Molecular Formula C17H31F3N3O3P
Molecular Weight 413.42
Catalog Number Size Price Quantity
R10-0011 -- $--

Product Introduction

TFA-Hexylaminolinker Phosphoramidite is used to insert a spacer arm in an oligonucleotide and may be added in multiple additions when a longer spacer is required.

Chemical Information

Synonyms TFA-aminolinker C6 phosphoramidite; 2-Cyanoethyl (6-(2,2,2-trifluoroacetamido)hexyl) diisopropylphosphoramidite; 6-(N-Trifluoroacetamido)hexyl-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
Purity ≥90%
IUPAC Name N-[6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexyl]-2,2,2-trifluoroacetamide
Canonical SMILES CC(C)N(C(C)C)P(OCCCCCCNC(=O)C(F)(F)F)OCCC#N
InChI InChI=1S/C17H31F3N3O3P/c1-14(2)23(15(3)4)27(26-13-9-10-21)25-12-8-6-5-7-11-22-16(24)17(18,19)20/h14-15H,5-9,11-13H2,1-4H3,(H,22,24)
InChI Key SMMKTKILBQHSFL-UHFFFAOYSA-N
Solubility good in acetonitrile, THF, DCM
Appearance Colorless, light yellow solid
Boiling Point 433.696°C at 760 mmHg

Product Specification

Storage Store at -20°C

Computed Properties

XLogP3 3.4
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 8
Rotatable Bond Count 14
Exact Mass 413.20551334 g/mol
Monoisotopic Mass 413.20551334 g/mol
Topological Polar Surface Area 74.6Ų
Heavy Atom Count 27
Formal Charge 0
Complexity 459
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 1
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

Patents

Publication NumberTitlePriority Date
WO-2022266658-A1 Methods of preparing bivalent molecules 2021-06-17
WO-2021195295-A1 Bifunctional molecules and methods of using thereof 2020-03-24
US-2021198671-A1 Protected antibody-drug and aptamer-drug conjugates 2019-12-27
WO-2021004379-A1 Fluorescently labeled nucleic acid and synthesis method therefor 2019-07-05
WO-2020186174-A1 Methods and systems for processing or analyzing oligonucleotide encoded molecules 2019-03-14
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