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TFA-Hexylaminolinker Phosphoramidite | CAS 133975-85-6
| Catalog Number | R10-0011 |
| Category | DNA Stains |
| Molecular Formula | C17H31F3N3O3P |
| Molecular Weight | 413.42 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
TFA-Hexylaminolinker Phosphoramidite is used to insert a spacer arm in an oligonucleotide and may be added in multiple additions when a longer spacer is required.
Chemical Information
Product Specification
Application
Computed Properties
Patents
| Synonyms | TFA-aminolinker C6 phosphoramidite; 2-Cyanoethyl (6-(2,2,2-trifluoroacetamido)hexyl) diisopropylphosphoramidite; 6-(N-Trifluoroacetamido)hexyl-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 5'-Amino-Modifier C6-TFA CE Phosphoramidite; Trifluoroacetyl-hexylamine-linker Phosphoramidite; 5'-Amino-Modifier C6-TFA CEP; Trifluoroacetyl cyanoethyl phosphoramidite amino-linker; C6 TFA linker amidite; TFA-Hexylaminolinker Amidite |
| Purity | ≥90% |
| IUPAC Name | N-[6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexyl]-2,2,2-trifluoroacetamide |
| Canonical SMILES | CC(C)N(C(C)C)P(OCCCCCCNC(=O)C(F)(F)F)OCCC#N |
| InChI | InChI=1S/C17H31F3N3O3P/c1-14(2)23(15(3)4)27(26-13-9-10-21)25-12-8-6-5-7-11-22-16(24)17(18,19)20/h14-15H,5-9,11-13H2,1-4H3,(H,22,24) |
| InChIKey | SMMKTKILBQHSFL-UHFFFAOYSA-N |
| Solubility | Soluble in Acetonitrile, DCM, THF |
| Appearance | Colorless, light yellow solid |
| Boiling Point | 433.7±45.0 °C at 760 mmHg |
| Storage | Store at -20 °C |
TFA-Hexylaminolinker Phosphoramidite is a versatile compound essential for synthesizing modified oligonucleotides with diverse applications across various fields. Here are four key applications:
Custom Oligonucleotide Synthesis: Researchers utilize TFA-Hexylaminolinker Phosphoramidite to introduce functional groups into oligonucleotides during synthesis, allowing for the attachment of various moieties, such as fluorophores or biotin. These labeled oligonucleotides play critical roles in applications ranging from DNA sequencing to probe development in molecular biology assays, demonstrating the compound’s versatility in functionalizing oligonucleotide structures with precision.
Oligonucleotide Therapeutics: At the forefront of oligonucleotide-based therapeutics advancement, TFA-Hexylaminolinker Phosphoramidite is instrumental in modifying oligonucleotides to improve stability, specificity, and delivery to target cells. By incorporating this compound, researchers enhance the efficacy of innovative treatments like antisense oligonucleotides and small interfering RNAs (siRNAs), paving the way for personalized precision medicine in combating genetic and infectious diseases.
Targeted Drug Delivery: Through the strategic use of TFA-Hexylaminolinker Phosphoramidite, therapeutic oligonucleotides can be linked to targeting molecules like antibodies or peptides for precise delivery to specific cells or tissues. This targeted approach can enhance therapeutic efficacy while minimizing off-target effects, transforming the treatment of diseases such as malignancies and other serious illnesses through tailored drug delivery mechanisms characterized by increased precision and efficacy.
Immobilizing DNA on Surfaces: In the domain of nucleic acid analysis and diagnostic device development, TFA-Hexylaminolinker Phosphoramidite plays a pivotal role in creating oligonucleotides with reactive groups for covalent attachment to solid surfaces like microarrays and biosensors. This immobilization process is indispensable for enabling high-throughput analysis of nucleic acids, ensuring the stable positioning of oligonucleotides for precise detection and analysis of target sequences, thereby propelling advancements in molecular diagnostics and research endeavors.
| XLogP3 | 3.4 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 14 |
| Exact Mass | 413.20551334 g/mol |
| Monoisotopic Mass | 413.20551334 g/mol |
| Topological Polar Surface Area | 74.6Ų |
| Heavy Atom Count | 27 |
| Formal Charge | 0 |
| Complexity | 459 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
| Publication Number | Title | Priority Date |
|---|---|---|
| WO-2022266658-A1 | Methods of preparing bivalent molecules | 2021-06-17 |
| WO-2021195295-A1 | Bifunctional molecules and methods of using thereof | 2020-03-24 |
| US-2021198671-A1 | Protected antibody-drug and aptamer-drug conjugates | 2019-12-27 |
| WO-2021004379-A1 | Fluorescently labeled nucleic acid and synthesis method therefor | 2019-07-05 |
| WO-2020186174-A1 | Methods and systems for processing or analyzing oligonucleotide encoded molecules | 2019-03-14 |
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