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Fluorescent Probes
Ion Fluorescent Probes
Calcium, Chloride and Other indicators
Rhod-2 sodium salt

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Rhod-2 sodium salt

Catalog Number	A14-0034
Category	Calcium, Chloride and Other indicators
Molecular Formula	C40H39N4Na3O11
Molecular Weight	820.7

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Product Introduction

Rhod-2 is a red fluorescent calcium indicator. It exhibits a significant shift in fluorescence intensity upon binding to calcium (ex max = 549 nm; calcium-free v. ex/em max = 552/581 nm; calcium-bound).

Chemical Information
Product Specification
Application

Synonyms	2,2'-((2-(2-(2-(bis(carboxylatomethyl)amino)-5-(6-(dimethylamino)-3-(dimethyliminio)-3H-xanthen-9-yl)phenoxy)ethoxy)-4-methylphenyl)azanediyl)diacetate, trisodium salt
Purity	≥90%
Canonical SMILES	CC1=CC(=C(C=C1)N(CC(=O)[O-])CC(=O)[O-])OCCOC2=CC(=C3C4=C(C=C(C=C4)N(C)C)OC5=C3C=CC(=C5)N(C)C)C=CC2=[N+](CC(=O)[O-])CC(=O)[O-].[Na+].[Na+].[Na+]
InChI	InChI=1S/C40H42N4O11.3Na/c1-24-6-12-30(43(20-36(45)46)21-37(47)48)34(16-24)53-14-15-54-35-17-25(7-13-31(35)44(22-38(49)50)23-39(51)52)40-28-10-8-26(41(2)3)18-32(28)55-33-19-27(42(4)5)9-11-29(33)40;;;/h6-13,16-19H,14-15,20-23H2,1-5H3,(H3-,45,46,47,48,49,50,51,52);;;/q;3*+1/p-3
InChIKey	MNYSEOSAHLNRCB-UHFFFAOYSA-K
Appearance	Solid Powder

Excitation	549 nm (Ca2+-free), 552 nm (Ca2+-bound)
Emission	581 nm (Ca2+-bound)
Storage	Store at -20°C

Rhod-2 sodium salt, a calcium indicator dye commonly employed in fluorescence microscopy and various biochemical applications, offers a multitude of versatile and impactful uses.

Intracellular Calcium Imaging: At the forefront of cellular research, Rhod-2 sodium salt plays a pivotal role in quantifying intracellular calcium concentrations in live cells. When bound to calcium ions, Rhod-2 emits a vivid fluorescent signal, enabling researchers to dynamically observe calcium fluctuations in real-time. This exceptional capability proves invaluable in elucidating complex cellular processes, such as muscle contraction, neurotransmitter release, and signal transduction, with unparalleled detail.

Cardiomyocyte Function Analysis: In the realm of cardiac science, Rhod-2 sodium salt serves as a vital tool for evaluating calcium dynamics and handling within cardiomyocytes. By introducing Rhod-2 into cardiomyocytes, scientists can meticulously track calcium transients, unraveling the intricate mechanisms governing cardiac excitation-contraction coupling. This application stands as a cornerstone in the study of heart diseases, offering crucial insights that may pave the way for groundbreaking therapeutic advancements.

Neuroscience Research: Delving into the depths of neuroscience, Rhod-2 sodium salt emerges as a key component in probing calcium signaling processes within neurons and glial cells. The ability to monitor calcium waves and oscillations in brain cells facilitates a deeper understanding of neuronal communication and information processing. Such investigations hold the potential to illuminate the underlying pathophysiology of neurological disorders, guiding the development of innovative neurotherapeutic strategies.

Drug Screening and Toxicology: In the realm of drug evaluation, Rhod-2 sodium salt proves to be an indispensable asset in assessing the impact of compounds on cellular calcium homeostasis. By tracking changes in calcium levels following drug administration, researchers can discern potential drug candidates or toxic effects with precision and efficiency. This application stands as a cornerstone in pharmaceutical development, offering critical insights for advancing drug discovery and ensuring safety in the realm of toxicology assessment.