ReZolve-ER™ | CAS 1404104-40-0

Catalog Number	A16-0064
Category	Endoplasmic Reticulum Fluorescent Probes
Molecular Formula	C21H12N7O3Re
Molecular Weight	596.6

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Product Introduction

ReZolve-ER™ is a fluorogenic probe that can be used to label the endoplasmic reticulum in live and fixed cells. It readily crosses live cell membranes thus is suitable for live cell imaging.

Chemical Information
Product Specification
Application

Synonyms	(OC-6-33)-tricarbonyl(1,10-phenanthroline-κN1,κN10)[4-(2H-tetrazol-5-yl-κN2)pyridinato]-rhenium
Appearance	Solid Powder

Excitation	405 nm
Emission	570 nm
Storage	Store at -20°C

ReZolve-ER™, a fluorescent probe custom-built for staining the endoplasmic reticulum (ER) in live cells, offers real-time visualization and analysis capabilities.

Cell Imaging: Widely embraced in cell biology, ReZolve-ER™ illuminates the endoplasmic reticulum—a pivotal cellular entity engaged in synthesizing proteins and lipids. This probe empowers researchers to scrutinize ER morphology, structure, and distribution in real-time across diverse experimental scenarios. High-resolution imagery rendered by ReZolve-ER™ delves deeper into the dynamic nature of the ER, shedding light on its pivotal role in cellular operations.

Drug Screening: Integral to drug discovery endeavors, ReZolve-ER™ emerges as a powerful ally in deciphering ER stress and dysfunction, critical facets in therapeutic development. Its utility lies in evaluating how potential drugs impact ER morphology and function, enabling researchers to pinpoint compounds that modulate ER stress pathways implicated in various diseases. By monitoring ER changes post-drug administration, scientists can unveil novel avenues for combating disease-related ER stress.

Disease Research: In the realm of disease investigation, focusing on conditions linked to ER stress and misfolded proteins, such as neurodegenerative ailments and diabetes, ReZolve-ER™ emerges as an invaluable asset. This probe aids in visualizing the pathological cascades associated with these diseases, allowing researchers to witness firsthand how maladies alter ER structure and exacerbate disease progression. Such insights are paramount in strategizing interventions to mitigate ER stress’s repercussions on cellular equilibrium.

Biotechnology Research: Leveraged in biotechnological spheres, ReZolve-ER™ plays a pivotal role in tracking ER-driven processes during protein synthesis and secretion in host cells employed for recombinant protein manufacturing. By offering a visual window into the ER, researchers can fine-tune conditions for optimal protein folding and secretion, thereby enhancing the yields and quality of biopharmaceuticals churned out in industrial milieus.