Azido-PEG5-Boc | 1448451-72-6

Azido-PEG5-Boc, a versatile bifunctional polyethylene glycol (PEG) derivative, finds extensive utility in diverse bioconjugation applications. Here are four key applications of Azido-PEG5-Boc:

Bioconjugation: The strategic application of Azido-PEG5-Boc in biomolecule conjugation through click chemistry, particularly with alkyne-functionalized compounds, enables precise modification of proteins, peptides, and other biomolecules while upholding their biological activity. These modifications play a pivotal role in developing advanced diagnostic tools and therapeutics, propelling the field of biomedicine into new realms of innovation.

Drug Delivery: Azido-PEG5-Boc offers a gateway to creating PEGylated drug constructs, enhancing the pharmacokinetic properties of drugs and bolstering their clinical efficacy. By improving the solubility, stability, and half-life of therapeutic agents, PEGylation facilitated by Azido-PEG5-Boc leads to superior clinical outcomes, particularly benefiting proteins and peptides vulnerable to rapid degradation within the biological milieu.

Surface Modification: An essential tool in surface modification, Azido-PEG5-Boc elevates the biocompatibility and functionality of nanoparticles, biosensors, and medical devices through innovative PEG attachment. This modification mitigates nonspecific binding, enhancing the targeted delivery of therapeutics and diagnostics, thus fostering the advancement of next-generation biomaterials and medical devices that hold great promise in revolutionizing healthcare solutions.

Proteomics: In the dynamic realm of proteomics research, Azido-PEG5-Boc emerges as a key player in labeling and enriching specific proteins or peptides for identification and quantification purposes. Leveraging the azido group for bio-orthogonal reactions, researchers can selectively tag proteins in complex mixtures, thus enabling a comprehensive exploration of protein functions and interactions within intricate biological systems.