Azido-PEG5-Boc | CAS 1448451-72-6

Name: Azido-PEG5-Boc
Brand: BOC Sciences
Rating: 5 (1 reviews)

Catalog Number	R14-0222
Category	Azides
Molecular Formula	C₁₆H₃₁N₃O₇
Molecular Weight	377.43

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Product Introduction

Azido-PEG5-Boc is a polyethylene glycol (PEG)-based PROTAC linker. Azido-PEG5-Boc can be used in the synthesis of a series of PROTACs.

Chemical Information
Product Specification
Application

Synonyms	Azido-PEG5-CH2CO2-t-Bu
Purity	98%
IUPAC Name	tert-butyl 2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetate
Canonical SMILES	CC(C)(C)OC(=O)COCCOCCOCCOCCOCCN=[N+]=[N-]
InChI	InChI=1S/C16H31N3O7/c1-16(2,3)26-15(20)14-25-13-12-24-11-10-23-9-8-22-7-6-21-5-4-18-19-17/h4-14H2,1-3H3
InChIKey	OUBLZQPJPYRIKU-UHFFFAOYSA-N

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Azido-PEG5-Boc, a versatile bifunctional polyethylene glycol (PEG) derivative, finds extensive utility in diverse bioconjugation applications. Here are four key applications of Azido-PEG5-Boc:

Bioconjugation: The strategic application of Azido-PEG5-Boc in biomolecule conjugation through click chemistry, particularly with alkyne-functionalized compounds, enables precise modification of proteins, peptides, and other biomolecules while upholding their biological activity. These modifications play a pivotal role in developing advanced diagnostic tools and therapeutics, propelling the field of biomedicine into new realms of innovation.

Drug Delivery: Azido-PEG5-Boc offers a gateway to creating PEGylated drug constructs, enhancing the pharmacokinetic properties of drugs and bolstering their clinical efficacy. By improving the solubility, stability, and half-life of therapeutic agents, PEGylation facilitated by Azido-PEG5-Boc leads to superior clinical outcomes, particularly benefiting proteins and peptides vulnerable to rapid degradation within the biological milieu.

Surface Modification: An essential tool in surface modification, Azido-PEG5-Boc elevates the biocompatibility and functionality of nanoparticles, biosensors, and medical devices through innovative PEG attachment. This modification mitigates nonspecific binding, enhancing the targeted delivery of therapeutics and diagnostics, thus fostering the advancement of next-generation biomaterials and medical devices that hold great promise in revolutionizing healthcare solutions.

Proteomics: In the dynamic realm of proteomics research, Azido-PEG5-Boc emerges as a key player in labeling and enriching specific proteins or peptides for identification and quantification purposes. Leveraging the azido group for bio-orthogonal reactions, researchers can selectively tag proteins in complex mixtures, thus enabling a comprehensive exploration of protein functions and interactions within intricate biological systems.