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Azido-PEG3-triethoxysilane | CAS 2243566-43-8
| Catalog Number | R14-0127 |
| Category | Azides |
| Molecular Formula | C18H38N4O7Si |
| Molecular Weight | 450.6 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Azido-PEG3-triethoxysilane is a PEG linker containing azido and triethoxysilane moieties. The azide can be used for copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN. The triethoxysilane moiety is used for surface modification. The hydrophilic PEG linkers increase the water solubility properties of compounds in aqueous media.
Chemical Information
Product Specification
Application
Computed Properties
| Synonyms | Azido-PEG3-amide-C3-triethoxysilane; 3-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}-N-[3-(triethoxysilyl)propyl]propanamide |
| Purity | 98% |
| IUPAC Name | 3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-N-(3-triethoxysilylpropyl)propanamide |
| Canonical SMILES | CCO[Si](CCCNC(=O)CCOCCOCCOCCN=[N+]=[N-])(OCC)OCC |
| InChI | InChI=1S/C18H38N4O7Si/c1-4-27-30(28-5-2,29-6-3)17-7-9-20-18(23)8-11-24-13-15-26-16-14-25-12-10-21-22-19/h4-17H2,1-3H3,(H,20,23) |
| InChIKey | BCFMWIGPFZSBNT-UHFFFAOYSA-N |
| Solubility | DMSO, DCM, DMF |
| Storage | -20 °C |
Azido-PEG3-triethoxysilane, a versatile silane coupling agent, finds diverse applications in scientific settings. Here are four key applications of Azido-PEG3-triethoxysilane:
Surface Modification: Widely utilized in materials science and nanotechnology, Azido-PEG3-triethoxysilane adeptly modifies surfaces of various substrates, including glass, metals, and nanoparticles. By forming stable monolayers and introducing functional azide groups, it enables further chemical alterations, enhancing the functionality of surfaces for advanced applications.
Bioconjugation: In the realm of bioconjugation, Azido-PEG3-triethoxysilane acts as a pivotal linker, connecting biomolecules to surfaces. The azide group facilitates click chemistry reactions, enabling precise attachment of proteins, antibodies, or other biomolecules. This process is indispensable for the development of biosensors, diagnostic tools, and targeted drug delivery systems, driving innovation in biotechnological applications.
Polymer Chemistry: Within polymer chemistry, Azido-PEG3-triethoxysilane seamlessly integrates into polymer networks to introduce azide functionality, allowing for post-polymerization modifications. This capability empowers the customization of polymer architectures, tailoring properties to specific requirements. Such modifications play a critical role in crafting advanced materials for diverse applications in biomedical, electronic, and environmental sectors.
Microarray Fabrication: Azido-PEG3-triethoxysilane plays a crucial role in the fabrication of microarrays for biological and chemical analyses. By creating uniform functionalized surfaces, it facilitates the immobilization of probes or analytes, enabling high-throughput screening. This enhances the sensitivity and specificity of microarray-based assays, driving advancements in genomics, proteomics, and clinical diagnostics with precision and efficiency.
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 9 |
| Rotatable Bond Count | 22 |
| Exact Mass | 450.25097610 g/mol |
| Monoisotopic Mass | 450.25097610 g/mol |
| Topological Polar Surface Area | 98.8Ų |
| Heavy Atom Count | 30 |
| Formal Charge | 0 |
| Complexity | 451 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
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