Azido-PEG2-PFP ester

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Azido-PEG2-PFP ester

Azido-PEG2-PFP ester | CAS 1393330-37-4

Catalog Number R14-0299
Category Azides
Molecular Formula C13H12F5N3O4
Molecular Weight 369.24
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Product Introduction

Azido-PEG2-PFP ester is a PEG-containing bioorthogonal conjugation building block that provides an azide handle for modular click-chemistry workflows. The molecule can be used to introduce a click-reactive group onto an antibody, peptide, linker intermediate, or payload-containing component, depending on the chemistry of its second terminal functionality. Its additional reactive group is pfp ester (amine-reactive) for antibody lysines/primary amines. The structure includes peg2 spacer to provide hydrophilic spacing. Conjugation can be performed using spaac with dbco/bcn-functionalized partner or cuaac with terminal alkyne partner, depending the complementary handle. The sequence and orientation of the coupling steps should be selected according to the functional groups carried by the two conjugation partners.

  • Chemical Information

  • Product Specification

  • Application

  • Computed Properties

  • Patents

Chemical Information

Synonyms perfluorophenyl 3-(2-(2-azidoethoxy)ethoxy)propanoate;
Purity ≥98%
IUPAC Name (2,3,4,5,6-pentafluorophenyl) 3-[2-(2-azidoethoxy)ethoxy]propanoate
SMILES C(COCCOCCN=[N+]=[N-])C(=O)OC1=C(C(=C(C(=C1F)F)F)F)F
InChI InChI=1S/C13H12F5N3O4/c14-8-9(15)11(17)13(12(18)10(8)16)25-7(22)1-3-23-5-6-24-4-2-20-21-19/h1-6H2
InChIKey FEXHEMGARNABFF-UHFFFAOYSA-N
Solubility DMF, DCM
Appearance Soild powder

Product Specification

Storage -20 °C

Application

Computed Properties

XLogP3 2.7
Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 11
Rotatable Bond Count 11
Exact Mass 369.07479668 g/mol
Monoisotopic Mass 369.07479668 g/mol
Topological Polar Surface Area 59.1Ų
Heavy Atom Count 25
Formal Charge 0
Complexity 453
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

Patents

Publication Number Title Priority Date
JP-2020114234-A XTEN conjugated composition and method of making same 2012-02-27

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