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Azido-PEG2-PFP ester

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Azido-PEG2-PFP ester

Azido-PEG2-PFP ester | 1393330-37-4

Catalog Number R14-0299
Category Azides
Molecular Formula C13H12F5N3O4
Molecular Weight 369.24
Catalog Number Size Price Quantity

Product Introduction

Azido-PEG2-PFP ester is a mixture of azide-functionalized polyethylene glycol (PEG) derivatives interleaved with pentafluorophenyl (PFP) ester moieties. This special compound is widely used as a coupling agent in the field of bioconjugation chemistry and shows unparalleled potential in efficient biomolecule modification. Whether proteins or peptides, azido-PEG2-PFP esters open up many possibilities for revolutionary applications, including drug delivery systems, targeted therapies, and transformative diagnostics.

Chemical Information

Synonyms perfluorophenyl 3-(2-(2-azidoethoxy)ethoxy)propanoate;
Purity ≥98%
IUPAC Name (2,3,4,5,6-pentafluorophenyl) 3-[2-(2-azidoethoxy)ethoxy]propanoate
Canonical SMILES C(COCCOCCN=[N+]=[N-])C(=O)OC1=C(C(=C(C(=C1F)F)F)F)F
InChI InChI=1S/C13H12F5N3O4/c14-8-9(15)11(17)13(12(18)10(8)16)25-7(22)1-3-23-5-6-24-4-2-20-21-19/h1-6H2
InChI Key FEXHEMGARNABFF-UHFFFAOYSA-N
Solubility DMF, DCM
Appearance Soild powder
  • Product Specification
  • Application
Storage -20 °C

Azido-PEG2-PFP ester, a versatile chemical reagent, is extensively utilized in bioconjugation and click chemistry applications. Explore four key applications of Azido-PEG2-PFP ester presented:

Protein Labeling: Positioned on the cutting edge of research, Azido-PEG2-PFP ester functions as a pivotal tool for the precise labeling of proteins. By interacting with amine groups on proteins, it introduces an azide functional group, laying the groundwork for subsequent click chemistry reactions. This groundbreaking technique empowers researchers to attach a diverse array of probes or tags to proteins, facilitating detailed tracking and imaging studies.

Drug Delivery Systems: Azido-PEG2-PFP ester emerges as a transformative force in the realm of drug delivery systems. Employed in drug delivery investigations, it works to modify nanoparticles or drug carriers. The conjugation of the azide group with alkyne-functionalized therapeutic agents enhances the targeting and delivery efficiency of the drug carrier system. This state-of-the-art methodology plays a pivotal role in shaping advanced and precise drug delivery mechanisms, propelling therapeutic efficacy to unprecedented levels.

Biomaterials Development: Within the sphere of biomaterials, Azido-PEG2-PFP ester assumes a crucial role in enhancing functionalities. By introducing azide groups onto surfaces, it facilitates the covalent attachment of bioactive molecules through click chemistry, thereby enhancing the biocompatibility and specificity of biomaterials utilized in tissue engineering and regenerative medicine. This innovative approach spearheads the development of tailored biomaterials with augmented properties, revolutionizing the field of biomedicine.

Molecular Imaging: Revolutionizing the landscape of molecular imaging, Azido-PEG2-PFP ester stands as a key component in formulating imaging agents for cutting-edge studies. Through the conjugation of imaging probes to biomolecules via azide-alkyne cycloaddition, researchers craft highly specific and stable imaging sensors. This advancement amplifies the capability to visualize and quantify biological processes in real-time, fostering a deeper understanding and diagnosis of diseases. A paradigm-shifting tool in the realm of molecular imaging, Azido-PEG2-PFP ester unlocks new horizons for innovative research endeavors.

Computed Properties

XLogP3 2.7
Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 11
Rotatable Bond Count 11
Exact Mass 369.07479668 g/mol
Monoisotopic Mass 369.07479668 g/mol
Topological Polar Surface Area 59.1Ų
Heavy Atom Count 25
Formal Charge 0
Complexity 453
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

Patents

Publication NumberTitlePriority Date
JP-2020114234-A XTEN conjugated composition and method of making same 2012-02-27
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