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3-(Azido-PEG5-amino)propanol | CAS 2228857-31-4
| Catalog Number | R14-0204 |
| Category | Azides |
| Molecular Formula | C15H32N4O6 |
| Molecular Weight | 364.4 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
3-(Azido-PEG5-amino)propanol is a PEG linker which contains an azide moiety and a terminal hydroxyl group. The azide is commonly used for copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN to form triazole linkages. The hydroxyl group can react to further derivatize the compound. The hydrophilic PEG spacer increases the water solubility of compounds in aqueous media.
Chemical Information
Product Specification
Application
Computed Properties
| Purity | 98% |
| IUPAC Name | 3-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethylamino]propan-1-ol |
| Canonical SMILES | C(CNCCOCCOCCOCCOCCOCCN=[N+]=[N-])CO |
| InChI | InChI=1S/C15H32N4O6/c16-19-18-4-7-22-9-11-24-13-15-25-14-12-23-10-8-21-6-3-17-2-1-5-20/h17,20H,1-15H2 |
| InChIKey | QVTMKPNWEOZQRR-UHFFFAOYSA-N |
| Storage | -20 °C |
3-(Azido-PEG5-amino)propanol, a versatile chemical compound, finds extensive utility in diverse scientific and medical realms. Here are four key applications of 3-(Azido-PEG5-amino)propanol:
Bioconjugation: At the forefront of bioconjugation techniques lies 3-(Azido-PEG5-amino)propanol, a pivotal component facilitating the linkage of biomolecules like proteins and nucleic acids through the azide-alkyne click chemistry reaction. This intricate process allows for the precise attachment of functional groups to biomolecules, ushering in a new era of targeted drug delivery systems and diagnostic tools. The inclusion of the PEG spacer adds flexibility and biocompatibility, elevating the effectiveness of conjugated biomolecules in groundbreaking ways.
Drug Delivery: In the dynamic realm of drug delivery research, 3-(Azido-PEG5-amino)propanol assumes a critical role in modifying drug molecules or carriers, thereby enhancing their solubility, stability, and bioavailability. By harnessing this compound to attach therapeutic agents, researchers can engineer prodrugs or conjugates that release active drugs in a controlled fashion. This innovative approach enables targeted delivery to specific tissues or cells, ultimately reducing side effects and optimizing therapeutic outcomes through a labyrinth of intricate chemical interactions.
Surface Functionalization: Delving into the realm of surface functionalization, 3-(Azido-PEG5-amino)propanol emerges as a key player in enhancing the interaction of materials such as nanoparticles, microarrays, and biosensors with biological molecules. The azide group unlocks avenues for further functionalization through click chemistry, empowering researchers to tailor surface properties for specific applications with unmatched precision and finesse. This tailored approach culminates in heightened sensitivity and specificity in biosensing and diagnostic assays, pushing the boundaries of scientific discovery and application.
Polymer Chemistry: Within the intricate landscape of polymer chemistry, 3-(Azido-PEG5-amino)propanol shines as an indispensable component for introducing azide groups into polymer chains. The integration of PEG imbues resulting polymers with enhanced hydrophilicity and biocompatibility, rendering them well-suited for a myriad of biomedical applications. These versatile functional polymers find resonance in diverse fields, ranging from tissue engineering and drug delivery systems to acting as antifouling coatings in cutting-edge medical devices, showcasing the myriad possibilities unlocked through innovative polymer chemistry methodologies.
| XLogP3 | -0.4 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 9 |
| Rotatable Bond Count | 21 |
| Exact Mass | 364.23218475 g/mol |
| Monoisotopic Mass | 364.23218475 g/mol |
| Topological Polar Surface Area | 92.8Ų |
| Heavy Atom Count | 25 |
| Formal Charge | 0 |
| Complexity | 306 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
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