NBD C6-Ceramide | 86701-10-2

Catalog Number	A16-0186
Category	Golgi Fluorescent Probes
Molecular Formula	C30H49N5O6
Molecular Weight	575.751

Catalog Number	Size	Price	Quantity
A16-0186	--	$--

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Product Introduction

NBD C6-ceramide is a green-fluorescent, cell-permeant analog of ceramide which is relatively selective for staining the trans-Golgi apparatus in both living and fixed cells.

Chemical Information
Product Specification
Application

Synonyms	N-(NBD-Aminohexanoyl)sphingosine
Canonical SMILES	CCCCCCCCCCCCCC=CC(C(CO)NC(=O)CCCCCNC1=CC=C(C2=NON=C12)[N+](=O)[O-])O
InChI	InChI=1S/C30H49N5O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-27(37)25(23-36)32-28(38)19-16-14-17-22-31-24-20-21-26(35(39)40)30-29(24)33-41-34-30/h15,18,20-21,25,27,31,36-37H,2-14,16-17,19,22-23H2,1H3,(H,32,38)/b18-15+/t25-,27+/m0/s1
InChI Key	HZIRBXILQRLFIK-VPZZKNKNSA-N
Appearance	Solid Powder

Excitation	460-470 nm
Emission	520-540 nm

NBD C6-Ceramide, a fluorescent analog of ceramide, a sphingolipid pivotal in cell signaling and apoptosis, offers myriad applications.

Apoptosis Studies: In the realm of apoptosis research, NBD C6-Ceramide shines as a beacon. Scientists leverage this fluorescent analog to probe the intricacies of programmed cell death mechanisms. By introducing this luminescent mimic into cells, researchers are empowered to witness ceramide-mediated apoptosis unfolding in real-time through fluorescence microscopy. This invaluable tool sheds light on the role of ceramide in cell death pathways.

Lipid Trafficking: The fluorescent properties of NBD C6-Ceramide unveil a world of possibilities in tracking the dynamic movements of sphingolipids across cellular landscapes. Researchers can visualize and trace the journey of ceramides from the Golgi apparatus to various organelles, unraveling the mysteries of lipid trafficking. This application is indispensable for delving into lipid metabolism and unraveling the complexities of membrane dynamics.

Signal Transduction: Unraveling the enigmatic realm of signal transduction, NBD C6-Ceramide emerges as a powerful tool for dissecting stress and immune response pathways. Scientists harness this analog to probe how ceramide influences signaling cascades that dictate inflammatory reactions or cell survival. Revelations gleaned from these studies pave the way for novel therapeutic strategies in combating inflammatory and autoimmune diseases.

Cancer Research: In the fight against cancer, NBD C6-Ceramide stands as a beacon of hope, offering insights into the impact of ceramide levels on tumor progression and treatment response. By integrating this fluorescent analog into cancer cells, researchers gain a window into how ceramide shapes cell proliferation, migration, and sensitivity to chemotherapeutic agents.

Applications of Fluorescent Probes & Dyes