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Mca-VDQVDGW-Lys(Dnp)-NH2
| Catalog Number | A18-0039 |
| Category | Fluorescent Enzyme Substrates |
| Molecular Formula | C60H74N14O21 |
| Molecular Weight | 1327.3 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| A18-0039 | -- | $-- |
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Product Introduction
Mca-VDQVDGW-Lys(Dnp)-NH2 is a fluorogenic substrate for caspase-7. It is cleaved by caspase-7 to release the fluorescent moiety 7-methoxycoumarin-4-acetyl (Mca), which can be used to quantify caspase-7 activity.
Chemical Information |
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|---|---|
| Synonyms | Caspase-7 Fluorogenic Substrate I; (3S,6S,9S,12S,18S,21S)-18-((1H-indol-3-yl)methyl)-6-(3-amino-3-oxopropyl)-21-carbamoyl-12-(carboxymethyl)-25-((2,4-dinitrophenyl)amino)-9-isopropyl-3-((S)-2-(2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetamido)-3-methylbutanamido)-4,7,10,13,16,19-hexaoxo-5,8,11,14,17,20-hexaazapentacosanoic acid |
| Purity | ≥95% |
| IUPAC Name | 3-[[(2S)-2-[[5-amino-2-[[(2S)-3-carboxy-2-[[2-[[2-(7-methoxy-2-oxochromen-4-yl)acetyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-5-oxopentanoyl]amino]-3-methylbutanoyl]amino]-4-[[2-[[1-[[(2S)-1-amino-6-(2,4-dinitroanilino)-1-oxohexan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-4-oxobutanoic acid |
| Canonical SMILES | CC(C)C(C(=O)NC(CC(=O)O)C(=O)NC(CCC(=O)N)C(=O)NC(C(C)C)C(=O)NC(CC(=O)O)C(=O)NCC(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CCCCNC3=C(C=C(C=C3)[N+](=O)[O-])[N+](=O)[O-])C(=O)N)NC(=O)CC4=CC(=O)OC5=C4C=CC(=C5)OC |
| InChI | InChI=1S/C60H74N14O21/c1-29(2)52(71-47(76)21-31-22-51(82)95-45-24-34(94-5)14-15-36(31)45)59(88)70-43(26-50(80)81)58(87)68-40(17-18-46(61)75)56(85)72-53(30(3)4)60(89)69-42(25-49(78)79)55(84)65-28-48(77)66-41(20-32-27-64-37-11-7-6-10-35(32)37)57(86)67-39(54(62)83)12-8-9-19-63-38-16-13-33(73(90)91)23-44(38)74(92)93/h6-7,10-11,13-16,22-24,27,29-30,39-43,52-53,63-64H,8-9,12,17-21,25-26,28H2,1-5H3,(H2,61,75)(H2,62,83)(H,65,84)(H,66,77)(H,67,86)(H,68,87)(H,69,89)(H,70,88)(H,71,76)(H,72,85)(H,78,79)(H,80,81)/t39-,40?,41?,42?,43-,52?,53-/m0/s1 |
| InChI Key | IAEXPKQPOUYJTI-UQRVRJOKSA-N |
- Product Specification
| Storage | Store at -20°C |
Computed Properties | |
|---|---|
| XLogP3 | 1.2 |
| Hydrogen Bond Donor Count | 14 |
| Hydrogen Bond Acceptor Count | 22 |
| Rotatable Bond Count | 36 |
| Exact Mass | 1326.51529542 g/mol |
| Monoisotopic Mass | 1326.51529542 g/mol |
| Topological Polar Surface Area | 549Ų |
| Heavy Atom Count | 95 |
| Formal Charge | 0 |
| Complexity | 2850 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 3 |
| Undefined Atom Stereocenter Count | 4 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Applications of Fluorescent Probes & Dyes
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