GSHtracer

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GSHtracer

GSHtracer | 1479071-34-5

Catalog Number A14-0003
Category Glutathione (GSH) Probes
Molecular Formula C21H21N3O3
Molecular Weight 363.41
Catalog Number Size Price Quantity
A14-0003 -- $--

Product Introduction

GSHtracer is a fluorescent probe for measuring of glutathione (GSH) levels.

Chemical Information

Synonyms 2-Cyano-N,N-dimethyl-3-(2,3,6,7-tetrahydro-11-oxo-1H,5H,11H-[1]benzopyrano[6,7,8-ij]quinolizin-10-yl)-2-propenamide
Purity ≥98% by HPLC
IUPAC Name (E)-2-cyano-N,N-dimethyl-3-(4-oxo-3-oxa-13-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1,5,7,9(17)-tetraen-5-yl)prop-2-enamide
Canonical SMILES CN(C)C(=O)C(=CC1=CC2=CC3=C4C(=C2OC1=O)CCCN4CCC3)C#N
InChI InChI=1S/C21H21N3O3/c1-23(2)20(25)16(12-22)11-15-10-14-9-13-5-3-7-24-8-4-6-17(18(13)24)19(14)27-21(15)26/h9-11H,3-8H2,1-2H3/b16-11+
InChI Key YCXQIYZKBAKCHQ-LFIBNONCSA-N
  • Product Specification
  • Application
Storage Store at -20°C

GSHtracer, a versatile tool for tracking and analyzing glutathione, a crucial antioxidant in diverse biological systems, exhibits a multitude of applications:

Oxidative Stress Research: Utilizing GSHtracer in the exploration of oxidative stress, a state characterized by the disparity between reactive oxygen species (ROS) and antioxidants within the body, researchers delve into the intricate dynamics. By monitoring glutathione levels, profound insights into cellular responses to oxidative insults are unearthed. This knowledge proves vital in unraveling the complexities of diseases linked to oxidative stress, including Alzheimer’s, Parkinson’s, and a spectrum of cardiovascular disorders.

Drug Metabolism Studies: Within pharmacology, GSHtracer serves as a pivotal tool for scrutinizing the involvement of glutathione in drug metabolism processes. Many pharmaceutical compounds undergo biotransformation, with glutathione conjugation playing a pivotal role in detoxification pathways. Leveraging GSHtracer, scientists meticulously observe the interactions between drugs and glutathione, contributing to the development of safer and more efficacious drug formulations.

Cancer Research: In the realm of oncology, GSHtracer emerges as a valuable asset enabling the monitoring of glutathione levels within tumor cells. Elevated glutathione levels in cancerous cells often confer resistance to chemotherapy regimens. By meticulously tracking these levels, researchers strategize interventions to modulate glutathione concentrations, thereby augmenting the effectiveness of anticancer therapies.

Cellular Health Monitoring: Deploying GSHtracer for the evaluation of cellular well-being under various experimental contexts, researchers gain insights into overall cellular health and viability. Glutathione levels within cells serve as a barometer of the cellular redox state and general health status. Employing GSHtracer in cell culture studies facilitates a nuanced understanding of how diverse treatments, toxins, or environmental stressors impact cellular functionality and survival.

Computed Properties

XLogP3 2.6
Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 5
Rotatable Bond Count 2
Exact Mass 363.15829154 g/mol
Monoisotopic Mass 363.15829154 g/mol
Topological Polar Surface Area 73.6Ų
Heavy Atom Count 27
Formal Charge 0
Complexity 760
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 1
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

Literatures

PMIDPublication DateTitleJournal
9426 1976-10-01 The particulate superoxide-forming system from human neutrophils. Properties of the system and further evidence supporting its participation in the respiratory burst The Journal of clinical investigation
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