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Cytochalasin D, BODIPY TMR Conjugate

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Cytochalasin D, BODIPY TMR Conjugate

Catalog Number	F01-0199
Category	BODIPY
Molecular Formula	C51H56BF2N3O3
Molecular Weight	887.81

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Product Introduction

Cytochalasin D, BODIPY TMR Conjugate is an orange-fluorescent derivative of cytochalasin D, an inhibitor of actin polymerization. This probe has been used for labeling actin filaments in live cells. It is relatively insensitive to environment and pH changes.

Chemical Information
Application

Synonyms	Cytochalasin D, EverFluor TMR Conjugate
Appearance	Solid Powder

Cytochalasin D BODIPY TMR Conjugate, a fluorescently labeled actin inhibitor, finds versatile applications in cell biology and imaging studies.

Cell Motility Studies: Utilizing Cytochalasin D BODIPY TMR Conjugate, researchers delve into cell motility dynamics by disrupting actin filament polymerization. By impeding the formation of actin networks, scientists witness alterations in cellular movement and morphology. This invaluable tool sheds light on the intricate mechanisms underlying cell migration, with profound implications for developmental biology and oncology research.

Live-Cell Imaging: With the BODIPY TMR tag facilitating fluorescent visualization, Cytochalasin D allows real-time monitoring of actin dynamics in live cells. By conjugating the tag to Cytochalasin D, scientists gain insights into the consequences of actin filament disruption, unraveling the nuances of cytoskeletal architecture and cellular organization. This application is instrumental for capturing dynamic processes like cell division and intracellular transport in action.

Drug Screening: In the realm of drug discovery, Cytochalasin D BODIPY TMR Conjugate emerges as a pivotal tool for screening and characterizing compounds affecting the actin cytoskeleton. Through assessing the impact of potential drugs on actin polymerization and stability, researchers gauge efficacy and toxicity profiles. This approach expedites the identification of therapeutics targeting actin-related cellular processes, propelling drug development efforts forward.

Cell Toxicity Assays: For exploring cellular toxicity induced by actin disruption, Cytochalasin D BODIPY TMR Conjugate serves as a foundational component in assay design. By scrutinizing cell viability and morphological alterations post-treatment, scientists unravel the repercussions on actin-dependent cellular functions. This application offers insights into the cytotoxic effects of environmental toxins and pharmaceutical agents on the actin cytoskeleton, enriching our understanding of cellular responses to external stimuli.