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Coumarin hydrazine | CAS 113707-87-2
| Catalog Number | A16-0027 |
| Category | Other Cell Fluorescent Probes |
| Molecular Formula | C10H10N2O2 |
| Molecular Weight | 190.2 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Coumarin hydrazine is an aromatic hydrazine-containing fluorophore for labeling aldehydes or ketones. Coumarin hydrazine acts as a fluorogenic sensor in live cells to detect carbonylated biomolecules that occur following oxidative stress.
Chemical Information
Product Specification
Application
| Synonyms | BzCH; CH-1; 7-hydrazino-4-methyl Coumarin; 7-hydrazinyl-4-methyl-2H-1-benzopyran-2-one |
| Purity | ≥90% |
| Canonical SMILES | CC1=CC(=O)OC2=C1C=CC(=C2)NN |
| InChI | InChI=1S/C10H10N2O2/c1-6-4-10(13)14-9-5-7(12-11)2-3-8(6)9/h2-5,12H,11H2,1H3 |
| InChIKey | ZGALTRTXIDNBJL-UHFFFAOYSA-N |
| Appearance | Solid Powder |
| Excitation | 365 nm |
| Emission | 430-550 nm |
| Storage | Store at -20°C |
Coumarin hydrazine is a versatile compound widely utilized in biological and chemical research. Here are some key applications of Coumarin hydrazine:
Fluorescent Probes: Coumarin hydrazine is commonly used as a fluorescent probe in biochemical assays and imaging studies. Its ability to emit fluorescence upon binding to specific targets makes it valuable for tracking biological molecules and cellular events. Researchers utilize this feature to visualize cellular processes in real-time and detect changes in the molecular environment.
Enzyme Activity Studies: Coumarin hydrazine is employed to study enzyme kinetics and activities in various biochemical pathways. By serving as a substrate analog or inhibitor, it allows the monitoring of enzymatic reactions through fluorescence changes. This application is crucial for understanding enzyme functions, characterizing new enzymes, and developing enzyme inhibitors for therapeutic purposes.
Drug Development: In pharmaceutical research, Coumarin hydrazine is used as a scaffold for designing novel therapeutic agents. By modifying the coumarin moiety, researchers can create derivatives with enhanced biological activity and selectivity towards specific targets. This approach aids in the discovery of new drugs with potential applications in treating diseases such as cancer and infectious diseases.
Chemical Sensing: Coumarin hydrazine is utilized in the design of chemical sensors for detecting various analytes, including metal ions and small organic molecules. Its fluorescence properties change in response to the presence of these analytes, providing a visual readout. This capability is harnessed for developing sensitive and selective sensors for environmental monitoring, clinical diagnostics, and industrial processes.
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