C6 NBD Ceramide | 94885-02-6

Catalog Number	A16-0059
Category	Golgi Fluorescent Probes
Molecular Formula	C30H49N5O6
Molecular Weight	575.74

Catalog Number	Size	Price	Quantity
A16-0059	--	$--

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Product Introduction

C6 NBD ceramide is a ceramide derivative that is tagged with a fluorescent group NBD. It has been used as a stain for Golgi apparatus.

Chemical Information
Product Specification
Application

Synonyms	N-C6-NBD-D-erythro-Sphingosine; N-[7-(4-nitrobenzo-2-oxa-1,3-diazole)]-6-aminocaproyl-D-erythro-sphingosine
Purity	≥98%
Shelf Life	1 Year
IUPAC Name	N-[(E,2S,3R)-1,3-dihydroxyoctadec-4-en-2-yl]-6-[(4-nitro-2,1,3-benzoxadiazol-7-yl)amino]hexanamide
Canonical SMILES	CCCCCCCCCCCCCC=CC(C(CO)NC(=O)CCCCCNC1=CC=C(C2=NON=C12)[N+](=O)[O-])O
InChI	InChI=1S/C30H49N5O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-27(37)25(23-36)32-28(38)19-16-14-17-22-31-24-20-21-26(35(39)40)30-29(24)33-41-34-30/h15,18,20-21,25,27,31,36-37H,2-14,16-17,19,22-23H2,1H3,(H,32,38)/b18-15+/t25-,27+/m0/s1
InChI Key	HZIRBXILQRLFIK-VPZZKNKNSA-N
Density	1.2±0.1 g/cm3
Appearance	Redish Brown Solid
Melting Point	>50°C (dec.)

Storage

Store at -20°C

C6 NBD Ceramide, a synthetic analog of natural ceramides coupled with a fluorescent marker, plays a pivotal role in cell biology and neuroscience research. Here are four key applications of C6 NBD Ceramide:

Lipid Metabolism Studies: Delving into the intricate realm of lipid metabolism, researchers utilize C6 NBD Ceramide to investigate the functions of ceramides and their profound effects on cellular activities. By harnessing its fluorescent properties, scientists can visualize the intricate distribution and trafficking of ceramides within cells, unraveling the mysteries of lipid signaling pathways and their implications in complex diseases like obesity and diabetes.

Apoptosis Research: At the forefront of apoptosis research, C6 NBD Ceramide shines as a valuable tool in unraveling the mechanisms of programmed cell death. Through its incorporation into cell cultures, scientists can closely monitor the accumulation of ceramides and their pivotal roles in apoptotic signaling pathways. This exploration is essential for deciphering how ceramides orchestrate cell death in diverse physiological and pathological scenarios, including the intricate landscape of cancer.

Membrane Dynamics: Illuminating the dynamics of membranes, C6 NBD Ceramide emerges as a beacon for studying the organization of lipid rafts and membrane structures. Its fluorescent nature enables researchers to visualize ceramide-enriched domains within the plasma membrane, shedding light on their involvement in crucial cellular processes such as signal transduction, endocytosis, and membrane fusion. This insight fuels a deeper comprehension of membrane biology and associated disorders, guiding future research and therapeutic advancements.

Experimental Therapeutics: Unveiling new horizons in drug development, C6 NBD Ceramide takes center stage in exploring its potential therapeutic applications. With its ability to induce apoptosis, this ceramide analog emerges as a promising candidate for anti-cancer therapies. Researchers delve into assessing the therapeutic efficacy of ceramide analogs, unraveling their impact on cancer cell viability, and laying the groundwork for innovative treatment strategies that hold the promise of revolutionizing cancer care.

Applications of Fluorescent Probes & Dyes